DegronMD

Uniprot ID: Q4AC94

Source protein: C2 domain-containing protein 3

Source gene: C2CD3

Class: DEG_SCF_FBW7_2

Location: 1155:1162

E3 ligase: FBXW7

DEGRON score: 0.8637

ASA_SCORE: 67.2

COIL: 0.7031

CONS_SCORE: 0.4677

DSS_SCORE: 0.3649

HELIX: 0.0225

FCONS_SCORE: 1.1336

RIG_SCORE: 0.8094

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1162K	TCGA-95-7948	LUAD	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	0.7022
p.E1162K	DO25133	LUAD	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	0.7022
p.L1167S	TCGA-A5-A2K3	UCEC	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	0.1944
p.L1167S	DO43899	UCEC	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	0.1944
p.L1155I	TCGA-BS-A0UF	UCEC	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	0.6063
p.L1155I	DO41488	UCEC	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	0.6063
p.G1149E	TCGA-CV-6952	HNSC	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	0.1667
p.G1149E	DO14240	HNSC	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	0.1667
p.E1162Q	TCGA-E7-A7XN	BLCA	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	0.6744
p.E1162Q	DO51878	BLCA	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	0.6744
p.N1169S	TCGA-IB-7651	PAAD	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	0.1389
p.N1169S	DO46657	PAAD	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	0.1389
p.F1153S	DO229275	THCA	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4AC94	C2 domain-containing protein 3	DEG_SCF_FBW7_2	1155:1162	LPLTPRIE	FBXW7	0.8637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons