DegronMD

Uniprot ID: Q8IWV7

Source protein: E3 ubiquitin-protein ligase UBR1

Source gene: UBR1

Class: DEG_APCC_DBOX_1

Location: 1590:1598

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7478

ASA_SCORE: 80.2222

COIL: 0.8733

CONS_SCORE: 0.4744

DSS_SCORE: 0.2229

HELIX: 0.0418

FCONS_SCORE: 1.2173

RIG_SCORE: 0.7876

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1580L	TCGA-50-6590	LUAD	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	0.0556
p.Q1580L	DO24692	LUAD	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	0.0556
p.V1585A	TCGA-B5-A3FC	UCEC	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	0.1944
p.V1585A	DO41871	UCEC	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	0.1944
p.R1589I	TCGA-CA-6717	COAD	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	0.3056
p.R1589I	DO8264	COAD	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	0.3056
p.R1591I	TCGA-DF-A2KV	UCEC	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	0.8102
p.R1591I	DO219771	UCEC	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	0.8102
p.L1597I	DO229015	LICA	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	0.6063
p.I1595L	SIDM01045	Endometrial Carcinoma	GDSC	KRNSLIELP	DEG_APCC_DBOX_1	0.6063
p.I1595L	ACH-000978	Endometrial/Uterine Cancer	CCLE	KRNSLIELP	DEG_APCC_DBOX_1	0.6063
p.I1595L	EN	endometrium	COSMIC	KRNSLIELP	DEG_APCC_DBOX_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_APCC_DBOX_1	1590:1598	KRNSLIELP	APC,CDC20,FZR1	0.7478	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons