DegronMD

Uniprot ID: Q14160

Source protein: Protein scribble homolog

Source gene: SCRIB

Class: DEG_SCF_FBW7_1

Location: 1542:1549

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 83.9875

COIL: 0.9603

CONS_SCORE: 0.3231

DSS_SCORE: 0.8305

HELIX: 0.0135

FCONS_SCORE: 1.0963

RIG_SCORE: 0.5069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1538K	SIDM00797	Melanoma	GDSC	PAPTPSPT	DEG_SCF_FBW7_1	0.2222
p.E1538K	ACH-000788	Skin Cancer	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	0.2222
p.E1538K	A2058	skin	COSMIC	PAPTPSPT	DEG_SCF_FBW7_1	0.2222
p.P1542L	SIDM00181	Bladder Carcinoma	GDSC	PAPTPSPT	DEG_SCF_FBW7_1	0.6471
p.S1541F	ACH-000931	Skin Cancer	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	0.75
p.A1543T	ACH-000995	Leukemia	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	0.6028
p.T1549P	ACH-001982	Metastasis	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	0.8142

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14160	Protein scribble homolog	DEG_SCF_FBW7_1	1542:1549	PAPTPSPT	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons