DegronMD

Uniprot ID: Q14160

Source protein: Protein scribble homolog

Source gene: SCRIB

Class: DEG_APCC_DBOX_1

Location: 1217:1225

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 78.2778

COIL: 0.7911

CONS_SCORE: 0.3827

DSS_SCORE: 0.4305

HELIX: 0.0897

FCONS_SCORE: 1.0559

RIG_SCORE: 0.6915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1218L	TCGA-55-6969	LUAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.8428
p.R1218L	TCGA-CV-7090	HNSC	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.8428
p.R1218L	DO14238	HNSC	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.8428
p.R1218L	DO24586	LUAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.8428
p.S1226F	TCGA-AA-3712	COAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.75
p.S1226F	DO9780	COAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.75
p.G1214D	TCGA-BR-6452	STAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.25
p.G1214D	DO38404	STAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.25
p.S1225C	TCGA-C5-A7X3	CESC	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.7541
p.S1225C	DO49893	CESC	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.7541
p.A1212V	TCGA-CK-5916	COAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.1944
p.A1212V	DO8786	COAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.1944
p.E1234Q	TCGA-CR-6472	HNSC	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.0833
p.E1234Q	DO15870	HNSC	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.0833
p.R1229L	TCGA-ER-A195	SKCM	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.2222
p.R1229L	TCGA-FS-A1ZQ	SKCM	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.2222
p.R1229L	DO37442	SKCM	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.2222
p.R1229L	DO47712	SKCM	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.2222
p.A1212E	TCGA-HF-A5NB	STAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	0.1944
p.A1212E	DO50127	STAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.1944
p.R1218W	DO233882	GACA	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.8634
p.H1217P	DO35606	PBCA	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	0.6583
p.G1235D	SIDM00884	Breast Carcinoma	GDSC	HRNSLESIS	DEG_APCC_DBOX_1	0.0556
p.G1235D	ACH-000699	Breast Cancer	CCLE	HRNSLESIS	DEG_APCC_DBOX_1	0.0556
p.G1235D	HCC1395	breast	COSMIC	HRNSLESIS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14160	Protein scribble homolog	DEG_APCC_DBOX_1	1217:1225	HRNSLESIS	APC,CDC20,FZR1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons