DegronMD

Uniprot ID: Q14160

Source protein: Protein scribble homolog

Source gene: SCRIB

Class: DEG_APCC_DBOX_1

Location: 1529:1537

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9694

ASA_SCORE: 87.8667

COIL: 0.5344

CONS_SCORE: 0.3084

DSS_SCORE: 0.7664

HELIX: 0.4498

FCONS_SCORE: 1.006

RIG_SCORE: 0.614

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1541F	ACH-000931	Skin Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	0.6667
p.S1523F	TCGA-EE-A3JA	SKCM	TCGA	TRGPLERLA	DEG_APCC_DBOX_1	0.6111
p.S1523F	DO220860	MELA	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	0.6111
p.S1523F	DO47625	SKCM	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	0.6111
p.S1523Y	DO229218	THCA	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	0.6111
p.E1538K	SIDM00797	Melanoma	GDSC	TRGPLERLA	DEG_APCC_DBOX_1	0.3056
p.E1538K	ACH-000788	Skin Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	0.3056
p.E1538K	A2058	skin	COSMIC	TRGPLERLA	DEG_APCC_DBOX_1	0.3056
p.R1527Q	SIDM00113	Kidney Carcinoma	GDSC	TRGPLERLA	DEG_APCC_DBOX_1	0.2778
p.R1527Q	ACH-001208	Kidney Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	0.2778
p.R1527Q	TK10	kidney	COSMIC	TRGPLERLA	DEG_APCC_DBOX_1	0.2778
p.G1526S	SIDM01735	Biliary Tract Carcinoma	GDSC	TRGPLERLA	DEG_APCC_DBOX_1	0.25
p.G1526S	ACH-000808	Bile Duct Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	0.25
p.R1522M	TCGA-BR-4368	STAD	TCGA	TRGPLERLA	DEG_APCC_DBOX_1	0.1389
p.R1522M	DO38715	STAD	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	0.1389

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14160	Protein scribble homolog	DEG_APCC_DBOX_1	1529:1537	TRGPLERLA	APC,CDC20,FZR1	0.9694	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons