DegronMD

Uniprot ID: Q14160

Source protein: Protein scribble homolog

Source gene: SCRIB

Class: DEG_COP1_1

Location: 1276:1287

E3 ligase: COP1

DEGRON score: 0.996

ASA_SCORE: 70.5417

COIL: 0.7681

CONS_SCORE: 0.2939

DSS_SCORE: 0.4992

HELIX: 0.0551

FCONS_SCORE: 0.9658

RIG_SCORE: 0.6362

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1280M	TCGA-60-2724	LUSC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.6097
p.V1280M	DO26540	LUSC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.6097
p.S1279R	TCGA-63-A5MS	LUSC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.8538
p.S1279R	DO217896	GACA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.8538
p.S1279R	DO219161	LUSC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.8538
p.G1290R	TCGA-AP-A059	UCEC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.25
p.G1290R	DO41361	UCEC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.25
p.L1271M	TCGA-BQ-7060	KIRP	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.1944
p.L1271M	DO20831	KIRP	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.1944
p.L1271V	TCGA-EE-A3AB	SKCM	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.1944
p.L1271V	DO222670	MELA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.1944
p.L1271V	DO38057	SKCM	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.1944
p.R1269C	TCGA-EY-A1GU	UCEC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.1389
p.R1269C	DO41518	UCEC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.1389
p.R1269C	ACH-000619	Head and Neck Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.1389
p.G1289R	TCGA-GV-A6ZA	BLCA	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.2778
p.G1289R	DO49776	BLCA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.2778
p.G1290V	TCGA-HE-7130	KIRP	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.25
p.G1290V	DO20776	KIRP	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.25
p.P1284L	TCGA-IR-A3LK	CESC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	0.7582
p.P1284L	DO44299	CESC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.7582
p.R1269H	DO230343	COCA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	0.1389
p.S1276G	SIDM00541	Colorectal Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.8104
p.S1276G	ACH-000926	Colon/Colorectal Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.8104
p.A1270T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.1667
p.A1270T	ACH-002256	Leukemia	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.1667
p.A1270T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.1667
p.A1277T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	SIDM00282	Colorectal Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	SIDM00358	Gastric Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	SIDM00599	Osteosarcoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	SIDM00997	Thyroid Gland Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	SIDM00302	Other Solid Cancers	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	SIDM01682	Gastric Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-000062	Lung Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-000110	Gastric Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-000144	Gastric Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-000998	Colon/Colorectal Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-001306	Thyroid Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-001526	Bone Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-001610	Brain Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	ACH-002149	Ovarian Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	RERF-LC-MS	lung	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	KGN	ovary	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	CW-2	large_intestine	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	RERF-GC-1B	stomach	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	8305C	thyroid	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.A1277T	HuO9	bone	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.6028
p.R1282G	SIDM00901	Endometrial Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	0.6457
p.R1282G	ACH-000940	Endometrial/Uterine Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.6457
p.R1282G	AN3-CA	endometrium	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.6457
p.A1272V	ACH-002396	Bone Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	0.2222
p.A1272V	Sarc9371	bone	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.2222
p.Q1277H	NCI-H2110	lung	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SAGSVQRVPSGA

Degron related mutations and impact score

Drug responses associated with SCRIB mutations

All proteins holding degron of SAGSVQRVPSGA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14160	Protein scribble homolog	DEG_COP1_1	1276:1287	SAGSVQRVPSGA	COP1	0.996	More...