DegronMD

Uniprot ID: Q14160

Source protein: Protein scribble homolog

Source gene: SCRIB

Class: DEG_APCC_DBOX_1

Location: 1621:1629

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7088

ASA_SCORE: 92.8222

COIL: 0.945

CONS_SCORE: 0.2826

DSS_SCORE: 0.8328

HELIX: 0.0136

FCONS_SCORE: 0.9391

RIG_SCORE: 0.5968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1611K	TCGA-AC-A2BK	BRCA	TCGA	GRRGLGPVP	DEG_APCC_DBOX_1	0.0556
p.E1611K	DO1328	BRCA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	0.0556
p.S1638G	DO233823	GACA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	0.0833
p.A1628T	DO232761	PBCA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	0.7139
p.A1628T	SIDM01307	Colorectal Carcinoma	GDSC	GRRGLGPVP	DEG_APCC_DBOX_1	0.7139
p.A1628T	SIDM00287	B-Lymphoblastic Leukemia	GDSC	GRRGLGPVP	DEG_APCC_DBOX_1	0.7139
p.G1630D	DO229234	THCA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	0.75
p.E1632D	SIDM00506	Small Cell Lung Carcinoma	GDSC	GRRGLGPVP	DEG_APCC_DBOX_1	0.25
p.S1614R	ACH-000879	Endometrial/Uterine Cancer	CCLE	GRRGLGPVP	DEG_APCC_DBOX_1	0.1389
p.R1622C	ACH-000940	Endometrial/Uterine Cancer	CCLE	GRRGLGPVP	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14160	Protein scribble homolog	DEG_APCC_DBOX_1	1621:1629	GRRGLGPVP	APC,CDC20,FZR1	0.7088	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons