DegronMD

Uniprot ID: Q14157

Source protein: Ubiquitin-associated protein 2-like

Source gene: UBAP2L

Class: DEG_COP1_1

Location: 972:981

E3 ligase: COP1

DEGRON score: 0.9913

ASA_SCORE: 81.5

COIL: 0.924

CONS_SCORE: 0.47

DSS_SCORE: 0.4549

HELIX: 0.0174

FCONS_SCORE: 0.8779

RIG_SCORE: 0.6853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S984F	TCGA-93-8067	LUAD	TCGA	TSSNTGVPDI	DEG_COP1_1	0.25
p.S984F	DO25113	LUAD	ICGC	TSSNTGVPDI	DEG_COP1_1	0.25
p.N975S	TCGA-AP-A0LM	UCEC	TCGA	TSSNTGVPDI	DEG_COP1_1	0.5958
p.N975S	DO43306	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	0.5958
p.P979S	TCGA-AX-A1CE	UCEC	TCGA	TSSNTGVPDI	DEG_COP1_1	0.6752
p.P979S	DO42280	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	0.6752
p.V978M	TCGA-CG-4442	STAD	TCGA	TSSNTGVPDI	DEG_COP1_1	0.7208
p.V978M	DO38380	STAD	ICGC	TSSNTGVPDI	DEG_COP1_1	0.7208
p.V978M	SIDM02017	Colorectal Carcinoma	GDSC	TSSNTGVPDI	DEG_COP1_1	0.7208
p.S987A	DO233251	GACA	ICGC	TSSNTGVPDI	DEG_COP1_1	0.1667
p.V985M	DO233616	GACA	ICGC	TSSNTGVPDI	DEG_COP1_1	0.2222
p.S974C	DO228188	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	0.7541
p.S974I	DO228948	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	0.7341
p.G983V	DO228974	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	0.2778
p.V969F	DO228971	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	0.25
p.A981T	DO219784	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	0.7139
p.A981T	DO42280	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	0.7139
p.Y986H	SIDM02071	Esophageal Carcinoma	GDSC	TSSNTGVPDI	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14157	Ubiquitin-associated protein 2-like	DEG_COP1_1	972:981	TSSNTGVPDI	COP1	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons