DegronMD

Uniprot ID: Q14157

Source protein: Ubiquitin-associated protein 2-like

Source gene: UBAP2L

Class: DEG_SPOP_SBC_1

Location: 686:690

E3 ligase: SPOP

DEGRON score: 0.9666

ASA_SCORE: 86.5

COIL: 0.9396

CONS_SCORE: 0.3516

DSS_SCORE: 0.6677

HELIX: 0.0216

FCONS_SCORE: 0.8277

RIG_SCORE: 0.6269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T699M	TCGA-AA-3864	COAD	TCGA	PNTTT	DEG_SPOP_SBC_1	0.0833
p.T699M	TCGA-E6-A2P8	UCEC	TCGA	PNTTT	DEG_SPOP_SBC_1	0.0833
p.T699M	DO8490	COAD	ICGC	PNTTT	DEG_SPOP_SBC_1	0.0833
p.T699M	DO40924	UCEC	ICGC	PNTTT	DEG_SPOP_SBC_1	0.0833
p.L679F	TCGA-AC-A23H	BRCA	TCGA	PNTTT	DEG_SPOP_SBC_1	0.1389
p.L679F	DO2401	BRCA	ICGC	PNTTT	DEG_SPOP_SBC_1	0.1389
p.S698C	TCGA-E5-A4U1	BLCA	TCGA	PNTTT	DEG_SPOP_SBC_1	0.1111
p.S698C	DO44061	BLCA	ICGC	PNTTT	DEG_SPOP_SBC_1	0.1111
p.T696A	DO50796	LIRI	ICGC	PNTTT	DEG_SPOP_SBC_1	0.1667
p.T699A	SIDM01664	Prostate Carcinoma	GDSC	PNTTT	DEG_SPOP_SBC_1	0.0833
p.T699A	ACH-000952	Prostate Cancer	CCLE	PNTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	686:690	PNTTT	SPOP	0.9666	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons