DegronMD - Q8WV16(DCAF4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E74K	TCGA-4Z-AA81	BLCA	TCGA	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1111
p.E74K	DO51868	BLCA	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1111
p.D48G	TCGA-56-6546	LUSC	TCGA	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.0833
p.D48G	TCGA-56-6546	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.25
p.D48G	TCGA-56-6546	LUSC	TCGA	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.D48G	DO26542	LUSC	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.0833
p.D48G	DO26542	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.25
p.D48G	DO26542	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.S62Y	TCGA-AJ-A3EL	UCEC	TCGA	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation altering degron motif	0.6009
p.S62Y	TCGA-AJ-A3EL	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.712
p.S50F	TCGA-AX-A06F	UCEC	TCGA	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1389
p.S50F	TCGA-AX-A06F	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.S50F	TCGA-AX-A06F	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1111
p.S50F	DO41752	UCEC	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1389
p.S50F	DO41752	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.S50F	DO41752	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1111
p.G44S	TCGA-EY-A5W2	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1389
p.G44S	DO228985	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1389
p.G44S	DO48177	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1389
p.S54L	TCGA-FS-A4FC	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7667
p.S54L	SIDM00596	Endometrial Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7667
p.S54L	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7667
p.S54L	HEC-1	endometrium	COSMIC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7667
p.P51L	TCGA-JY-A93E	ESCA	TCGA	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7582
p.R50C	DO51634	CESC	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1389
p.R50C	DO51634	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.R50C	DO51634	CESC	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1111
p.R50C	DO42033	UCEC	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1389
p.R50C	DO42033	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.R50C	DO42033	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1111
p.R50C	SK-UT-1	soft tissue	COSMIC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1389
p.R50C	SK-UT-1	soft tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.R50C	SK-UT-1	soft tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1111
p.L45I	DO11166	GBM	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.Q60H	DO228948	LICA	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation altering degron motif	0.7582
p.Q60H	DO228948	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7582
p.C43F	DO229029	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1111
p.M54I	DO229031	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7618
p.M54I	DO37444	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7618
p.H47Q	DO27357	LUSC	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.0556
p.H47Q	DO27357	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.S71R	DO228338	MALY	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1944
p.S71R	DO228338	MALY	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.S71R	DG-75	haematopoietic and lymphoid tissue	COSMIC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1944
p.S71R	DG-75	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.P51S	DO222653	MELA	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.6752
p.E48K	DO220260	SARC	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.0833
p.E48K	DO220260	SARC	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.25
p.E48K	DO220260	SARC	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.A46V	DO38063	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1944
p.A46S	DO38165	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1944
p.A68T	DO51759	STAD	ICGC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.2778
p.A68T	DO51759	STAD	ICGC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1667
p.E49K	SIDM00607	Glioblastoma	GDSC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1111
p.E49K	SIDM00607	Glioblastoma	GDSC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2778
p.E49K	SIDM00607	Glioblastoma	GDSC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.E49K	ACH-000622	Brain Cancer	CCLE	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1111
p.E49K	ACH-000622	Brain Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2778
p.E49K	ACH-000622	Brain Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.E49K	KNS-42	central nervous system	COSMIC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation rewiring degron network	0.1111
p.E49K	KNS-42	central nervous system	COSMIC	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2778
p.E49K	KNS-42	central nervous system	COSMIC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.S43Y	ACH-000177	Prostate Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1111
p.R62L	JJN-3	haematopoietic and lymphoid tissue	COSMIC	TAGTSSVPEL	DEG_COP1_1	57:66	Mutation altering degron motif	0.8428
p.R62L	JJN-3	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.8428

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCAF4

UniProt ID: Q8WV16

Entrez ID: 26094

Protein name: DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCAF4 in