DegronMD

Uniprot ID: Q8WV16

Source protein: DDB1- and CUL4-associated factor 4

Source gene: DCAF4

Class: DEG_COP1_1

Location: 57:66

E3 ligase: COP1

DEGRON score: 0.9921

ASA_SCORE: 78.56

COIL: 0.9458

CONS_SCORE: 0.3051

DSS_SCORE: 0.6084

HELIX: 0.0158

FCONS_SCORE: 0.809

RIG_SCORE: 0.6023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E74K	TCGA-4Z-AA81	BLCA	TCGA	TAGTSSVPEL	DEG_COP1_1	0.1111
p.E74K	DO51868	BLCA	ICGC	TAGTSSVPEL	DEG_COP1_1	0.1111
p.D48G	TCGA-56-6546	LUSC	TCGA	TAGTSSVPEL	DEG_COP1_1	0.0833
p.D48G	DO26542	LUSC	ICGC	TAGTSSVPEL	DEG_COP1_1	0.0833
p.S62Y	TCGA-AJ-A3EL	UCEC	TCGA	TAGTSSVPEL	DEG_COP1_1	0.6009
p.S50F	TCGA-AX-A06F	UCEC	TCGA	TAGTSSVPEL	DEG_COP1_1	0.1389
p.S50F	DO41752	UCEC	ICGC	TAGTSSVPEL	DEG_COP1_1	0.1389
p.R50C	DO51634	CESC	ICGC	TAGTSSVPEL	DEG_COP1_1	0.1389
p.R50C	DO42033	UCEC	ICGC	TAGTSSVPEL	DEG_COP1_1	0.1389
p.R50C	SK-UT-1	soft_tissue	COSMIC	TAGTSSVPEL	DEG_COP1_1	0.1389
p.Q60H	DO228948	LICA	ICGC	TAGTSSVPEL	DEG_COP1_1	0.7582
p.H47Q	DO27357	LUSC	ICGC	TAGTSSVPEL	DEG_COP1_1	0.0556
p.S71R	DO228338	MALY	ICGC	TAGTSSVPEL	DEG_COP1_1	0.1944
p.S71R	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	TAGTSSVPEL	DEG_COP1_1	0.1944
p.E48K	DO220260	SARC	ICGC	TAGTSSVPEL	DEG_COP1_1	0.0833
p.A68T	DO51759	STAD	ICGC	TAGTSSVPEL	DEG_COP1_1	0.2778
p.E49K	SIDM00607	Glioblastoma	GDSC	TAGTSSVPEL	DEG_COP1_1	0.1111
p.E49K	ACH-000622	Brain Cancer	CCLE	TAGTSSVPEL	DEG_COP1_1	0.1111
p.E49K	KNS-42	central_nervous_system	COSMIC	TAGTSSVPEL	DEG_COP1_1	0.1111
p.R62L	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	TAGTSSVPEL	DEG_COP1_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WV16	DDB1- and CUL4-associated factor 4	DEG_COP1_1	57:66	TAGTSSVPEL	COP1	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons