DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PSTSS
Uniprot ID:
Q00987
Source protein:
E3 ubiquitin-protein ligase Mdm2
Source gene:
MDM2
Class:
DEG_SPOP_SBC_1
Location:
397:401
E3 ligase:
SPOP
DEGRON score:
0.9972
ASA_SCORE:
75.62
COIL:
0.8978
CONS_SCORE:
0.4558
DSS_SCORE:
0.6848
HELIX:
0.0724
FCONS_SCORE:
1.1751
RIG_SCORE:
0.5822
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S400C
DO44794
LICA
ICGC
PSTSS
DEG_SPOP_SBC_1
0.7541
p.S400N
ACH-000410
Bone Cancer
CCLE
PSTSS
DEG_SPOP_SBC_1
0.7069
p.S400N
Saos-2
bone
COSMIC
PSTSS
DEG_SPOP_SBC_1
0.7069
p.D399E
TCGA-RD-A8NB
STAD
TCGA
PSTSS
DEG_SPOP_SBC_1
0.6758
p.L405F
DO229036
LICA
ICGC
PSTSS
DEG_SPOP_SBC_1
0.6667
p.I404S
SNU-81
large_intestine
COSMIC
PSTSS
DEG_SPOP_SBC_1
0.25
p.E390Q
DO23762
LUAD
ICGC
PSTSS
DEG_SPOP_SBC_1
0.1389
p.A409V
DO41871
UCEC
ICGC
PSTSS
DEG_SPOP_SBC_1
0.1111
p.I410S
SIDM00193
Colorectal Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
0.0833
p.I410S
SNU-81
large_intestine
COSMIC
PSTSS
DEG_SPOP_SBC_1
0.0833
p.M410I
ML-2
haematopoietic_and_lymphoid_tissue
COSMIC
PSTSS
DEG_SPOP_SBC_1
0.0833
p.E411G
DO218347
BRCA
ICGC
PSTSS
DEG_SPOP_SBC_1
0.0556
p.Y411C
SIDM01387
Small Cell Lung Carcinoma
GDSC
PSTSS
DEG_SPOP_SBC_1
0.0556
Showing 1 to 13 of 13 entries
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Drug responses associated with MDM2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
SIDM00145
ALL|lymphoblastic_leukemia
p.D386V (Yes)
GDSC
Nutlin-3a (-)
3.315
SIDM00145
ALL|lymphoblastic_leukemia
p.D386V (Yes)
GDSC
Serdemetan
13.9015
SIDM00145
ALL|lymphoblastic_leukemia
p.D386V (Yes)
GDSC
Nutlin-3a (-)
1.0069
SIDM00364
ALL|lymphoblastic_leukemia
p.T371fs*5 (No)
GDSC
Nutlin-3a (-)
5.9454
SIDM00364
ALL|lymphoblastic_leukemia
p.T371fs*5 (No)
GDSC
Serdemetan
13.2539
SIDM00364
ALL|lymphoblastic_leukemia
p.T371fs*5 (No)
GDSC
Nutlin-3a (-)
5.5112
SIDM00433
ALL|lymphoblastic_T_cell_leukaemia
p.E210G (No)
GDSC
Nutlin-3a (-)
15.9098
SIDM00433
ALL|lymphoblastic_T_cell_leukaemia
p.E210G (No)
GDSC
Serdemetan
15.7649
SIDM00433
ALL|lymphoblastic_T_cell_leukaemia
p.E210G (No)
GDSC
Nutlin-3a (-)
21.911
SIDM00970
BLCA|bladder
p.H134D (No)
GDSC
Nutlin-3a (-)
61.8194
SIDM00970
BLCA|bladder
p.H134D (No)
GDSC
Serdemetan
2.543
SIDM00970
BLCA|bladder
p.H134D (No)
GDSC
Nutlin-3a (-)
438.69
ACH-000748
Bone Cancer
p.E302D (No)
CCLE
Nutlin-3
6.4565
ACH-000410
Bone Cancer
p.S400N (Yes)
CCLE
Nutlin-3
8
SIDM00878
BRCA|breast
p.E338_G341delEDKG (No)
GDSC
Nutlin-3a (-)
33.7689
SIDM00878
BRCA|breast
p.E338_G341delEDKG (No)
GDSC
Serdemetan
11.453
SIDM00878
BRCA|breast
p.E338_G341delEDKG (No)
GDSC
Nutlin-3a (-)
65.786
SIDM00878
BRCA|breast
p.E338K (No)
GDSC
Nutlin-3a (-)
33.7689
SIDM00878
BRCA|breast
p.E338K (No)
GDSC
Serdemetan
11.453
SIDM00878
BRCA|breast
p.E338K (No)
GDSC
Nutlin-3a (-)
65.786
ACH-000111
Breast Cancer
p.LKL35fs (No)
CCLE
Nutlin-3
8
ACH-000930
Breast Cancer
p.EDKG307del (No)
CCLE
Nutlin-3
8
ACH-000985
Colon/Colorectal Cancer
p.P289fs (No)
CCLE
Nutlin-3
8
SIDM00217
COREAD|large_intestine
p.T371fs*2 (No)
GDSC
Nutlin-3a (-)
134.77
SIDM00498
COREAD|large_intestine
p.D52N (No)
GDSC
Nutlin-3a (-)
150.1991
Showing 1 to 25 of 75 entries
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All proteins holding degron of PSTSS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKA4
A-kinase anchor protein 11
DEG_SPOP_SBC_1
248:252
PSTSS
SPOP
0.9869
More...
Q6ULP2
Aftiphilin
DEG_SPOP_SBC_1
926:930
PSTSS
SPOP
0.8606
More...
Q8N9B4
Ankyrin repeat domain-containing protein 42
DEG_SPOP_SBC_1
9:13
PSTSS
SPOP
0.7987
More...
Q96P50
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
DEG_SPOP_SBC_1
384:388
PSTSS
SPOP
0.8937
More...
Q9UKL3
CASP8-associated protein 2
DEG_SPOP_SBC_1
1550:1554
PSTSS
SPOP
0.9951
More...
Q3L8U1
Chromodomain-helicase-DNA-binding protein 9
DEG_SPOP_SBC_1
2774:2778
PSTSS
SPOP
0.6499
More...
O60641
Clathrin coat assembly protein AP180
DEG_SPOP_SBC_1
705:709
PSTSS
SPOP
0.9214
More...
Q13620
Cullin-4B
DEG_SPOP_SBC_1
96:100
PSTSS
SPOP
0.9962
More...
Q8WYN3
Cysteine/serine-rich nuclear protein 3
DEG_SPOP_SBC_1
42:46
PSTSS
SPOP
0.9388
More...
Q8WV16
DDB1- and CUL4-associated factor 4
DEG_SPOP_SBC_1
51:55
PSTSS
SPOP
0.7339
More...
Q58WW2
DDB1- and CUL4-associated factor 6
DEG_SPOP_SBC_1
411:415
PSTSS
SPOP
0.8661
More...
A6NNA5
Dorsal root ganglia homeobox protein
DEG_SPOP_SBC_1
228:232
PSTSS
SPOP
0.9943
More...
Q9ULT8
E3 ubiquitin-protein ligase HECTD1
DEG_SPOP_SBC_1
737:741
PSTSS
SPOP
0.9725
More...
Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
DEG_SPOP_SBC_1
2191:2195
PSTSS
SPOP
0.9386
More...
Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
DEG_SPOP_SBC_1
2949:2953
PSTSS
SPOP
0.8713
More...
Q00987
E3 ubiquitin-protein ligase Mdm2
DEG_SPOP_SBC_1
156:160
PSTSS
SPOP
0.9632
More...
Q00987
E3 ubiquitin-protein ligase Mdm2
DEG_SPOP_SBC_1
397:401
PSTSS
SPOP
0.9972
More...
Q14241
Elongin-A
DEG_SPOP_SBC_1
753:757
PSTSS
SPOP
0.997
More...
Q9UQC2
GRB2-associated-binding protein 2
DEG_SPOP_SBC_1
630:634
PSTSS
SPOP
0.9605
More...
Q2KJY2
Kinesin-like protein KIF26B
DEG_SPOP_SBC_1
405:409
PSTSS
SPOP
0.9032
More...
A6NMS7
Leucine-rich repeat-containing protein 37A
DEG_SPOP_SBC_1
1256:1260
PSTSS
SPOP
0.9871
More...
Q96JG8
Melanoma-associated antigen D4
DEG_SPOP_SBC_1
716:720
PSTSS
SPOP
0.6971
More...
Q9Y4B5
Microtubule cross-linking factor 1
DEG_SPOP_SBC_1
1408:1412
PSTSS
SPOP
0.9928
More...
P46821
Microtubule-associated protein 1B
DEG_SPOP_SBC_1
1730:1734
PSTSS
SPOP
0.9838
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3974:3978
PSTSS
SPOP
0.8169
More...
Showing 1 to 25 of 60 entries
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