DegronMD - O75167(PHACTR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S246P	TCGA-19-5956	GBM	TCGA	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2222
p.R80Q	TCGA-AX-A1CE	UCEC	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7329
p.R80Q	DO42280	UCEC	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7329
p.R80Q	SIDM01164	Glioma	GDSC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7329
p.R80Q	ACH-000883	Brain Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7329
p.R80Q	SW1783	central nervous system	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7329
p.R80L	TCGA-B5-A11E	UCEC	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.8428
p.R80L	DO41644	UCEC	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.8428
p.E152K	TCGA-BR-8373	STAD	TCGA	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.0833
p.E152K	TCGA-W3-AA1V	SKCM	TCGA	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.0833
p.E130K	TCGA-DK-A6AV	BLCA	TCGA	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.0833
p.E130K	DO48575	BLCA	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.0833
p.E85G	TCGA-E2-A15H	BRCA	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7199
p.E85G	DO4473	BRCA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7199
p.S248L	TCGA-EI-6917	READ	TCGA	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation substituting flanking lysine	0.2778
p.S248L	SIDM00357	Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation substituting flanking lysine	0.2778
p.S248L	RERF-LC-FM	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation substituting flanking lysine	0.2778
p.D149N	TCGA-EO-A22R	UCEC	TCGA	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.1667
p.D149N	DO42713	UCEC	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.1667
p.K93N	TCGA-FS-A1ZJ	SKCM	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1111
p.K93N	DO37956	SKCM	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1111
p.E244K	DO48414	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2778
p.K252T	DO48446	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0556
p.Q238H	DO2401	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.7582
p.E237K	DO8514	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation blocking phosphorylation signal	0.75
p.E237K	DO47737	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation blocking phosphorylation signal	0.75
p.T69S	DO234294	ESAD	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1111
p.S135Y	DO233941	GACA	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.2222
p.V136L	DO228971	LICA	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.25
p.E85D	DO229022	LICA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.6758
p.L95F	DO229006	LICA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.0556
p.G134V	DO229008	LICA	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.1944
p.S78F	DO222557	MELA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7982
p.E232K	DO222632	MELA	ICGC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.E145K	DO222875	MELA	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.2778
p.P241H	DO38016	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.7694
p.A152T	DO51276	SKCM	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.0833
p.A152T	DO47859	STAD	ICGC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.0833
p.A71T	SIDM00107	Melanoma	GDSC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1667
p.A71T	ACH-000425	Skin Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1667
p.A71T	ACH-002004	Skin Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1667
p.A71T	UACC-62	skin	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1667
p.R67T	SIDM00631	Breast Carcinoma	GDSC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation blocking phosphorylation signal	0.5
p.R67T	ACH-001358	Breast Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation blocking phosphorylation signal	0.5
p.R67T	MDA-MB-330	breast	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation blocking phosphorylation signal	0.5
p.S243C	SIDM00492	Glioblastoma	GDSC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.S243C	AM-38	central nervous system	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.T241I	SIDM00265	Ewing's Sarcoma	GDSC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.7078
p.T241I	ES3	bone	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.7078
p.P241S	ACH-000873	Esophageal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.6752
p.P241S	KYSE-270	oesophagus	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.6752
p.G132S	ACH-001274	Sarcoma	CCLE	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.1389
p.P230S	KYSE-270	oesophagus	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.T150I	ES3	bone	COSMIC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.1389
p.T230I	ES3	bone	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.S232C	AM-38	central nervous system	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.R69Q	SW1783	central nervous system	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1111
p.R137Q	SW1783	central nervous system	COSMIC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.2778
p.P248T	JEG-3	placenta	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation substituting flanking lysine	0.2778
p.S152C	AM-38	central nervous system	COSMIC	KKENT	DEG_APCC_KENBOX_2	139:143	Mutation rewiring degron network	0.0833
p.S237L	RERF-LC-FM	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	238:242	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHACTR2

UniProt ID: O75167

Entrez ID: 9749

Protein name: Phosphatase and actin regulator 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHACTR2 in