DegronMD

Uniprot ID: O75167

Source protein: Phosphatase and actin regulator 2

Source gene: PHACTR2

Class: DEG_APCC_KENBOX_2

Location: 139:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5184

ASA_SCORE: 114.62

COIL: 0.6964

CONS_SCORE: 0.326

DSS_SCORE: 0.8703

HELIX: 0.3056

FCONS_SCORE: 0.9379

RIG_SCORE: 0.5591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E152K	TCGA-BR-8373	STAD	TCGA	KKENT	DEG_APCC_KENBOX_2	0.0833
p.E152K	TCGA-W3-AA1V	SKCM	TCGA	KKENT	DEG_APCC_KENBOX_2	0.0833
p.E130K	TCGA-DK-A6AV	BLCA	TCGA	KKENT	DEG_APCC_KENBOX_2	0.0833
p.E130K	DO48575	BLCA	ICGC	KKENT	DEG_APCC_KENBOX_2	0.0833
p.D149N	TCGA-EO-A22R	UCEC	TCGA	KKENT	DEG_APCC_KENBOX_2	0.1667
p.D149N	DO42713	UCEC	ICGC	KKENT	DEG_APCC_KENBOX_2	0.1667
p.S135Y	DO233941	GACA	ICGC	KKENT	DEG_APCC_KENBOX_2	0.2222
p.V136L	DO228971	LICA	ICGC	KKENT	DEG_APCC_KENBOX_2	0.25
p.G134V	DO229008	LICA	ICGC	KKENT	DEG_APCC_KENBOX_2	0.1944
p.E145K	DO222875	MELA	ICGC	KKENT	DEG_APCC_KENBOX_2	0.2778
p.A152T	DO51276	SKCM	ICGC	KKENT	DEG_APCC_KENBOX_2	0.0833
p.A152T	DO47859	STAD	ICGC	KKENT	DEG_APCC_KENBOX_2	0.0833
p.G132S	ACH-001274	Sarcoma	CCLE	KKENT	DEG_APCC_KENBOX_2	0.1389
p.T150I	ES3	bone	COSMIC	KKENT	DEG_APCC_KENBOX_2	0.1389
p.R137Q	SW1783	central_nervous_system	COSMIC	KKENT	DEG_APCC_KENBOX_2	0.2778
p.S152C	AM-38	central_nervous_system	COSMIC	KKENT	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75167	Phosphatase and actin regulator 2	DEG_APCC_KENBOX_2	139:143	KKENT	APC,CDC20,FZR1	0.5184	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons