DegronMD

Uniprot ID: O75167

Source protein: Phosphatase and actin regulator 2

Source gene: PHACTR2

Class: DEG_APCC_DBOX_1

Location: 77:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8761

ASA_SCORE: 98.6222

COIL: 0.7343

CONS_SCORE: 0.4286

DSS_SCORE: 0.4476

HELIX: 0.1953

FCONS_SCORE: 1.0604

RIG_SCORE: 0.759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R80Q	TCGA-AX-A1CE	UCEC	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	0.7329
p.R80Q	DO42280	UCEC	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.7329
p.R80Q	SIDM01164	Glioma	GDSC	RRGVLKELP	DEG_APCC_DBOX_1	0.7329
p.R80Q	ACH-000883	Brain Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	0.7329
p.R80Q	SW1783	central_nervous_system	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	0.7329
p.R80L	TCGA-B5-A11E	UCEC	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	0.8428
p.R80L	DO41644	UCEC	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.8428
p.E85G	TCGA-E2-A15H	BRCA	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	0.7199
p.E85G	DO4473	BRCA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.7199
p.K93N	TCGA-FS-A1ZJ	SKCM	TCGA	RRGVLKELP	DEG_APCC_DBOX_1	0.1111
p.K93N	DO37956	SKCM	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.1111
p.T69S	DO234294	ESAD	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.1111
p.E85D	DO229022	LICA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.6758
p.L95F	DO229006	LICA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.0556
p.S78F	DO222557	MELA	ICGC	RRGVLKELP	DEG_APCC_DBOX_1	0.7982
p.A71T	SIDM00107	Melanoma	GDSC	RRGVLKELP	DEG_APCC_DBOX_1	0.1667
p.A71T	ACH-000425	Skin Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	0.1667
p.A71T	ACH-002004	Skin Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	0.1667
p.A71T	UACC-62	skin	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	0.1667
p.R67T	SIDM00631	Breast Carcinoma	GDSC	RRGVLKELP	DEG_APCC_DBOX_1	0.5
p.R67T	ACH-001358	Breast Cancer	CCLE	RRGVLKELP	DEG_APCC_DBOX_1	0.5
p.R67T	MDA-MB-330	breast	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	0.5
p.R69Q	SW1783	central_nervous_system	COSMIC	RRGVLKELP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75167	Phosphatase and actin regulator 2	DEG_APCC_DBOX_1	77:85	RRGVLKELP	APC,CDC20,FZR1	0.8761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons