DegronMD - Q6ULP2(AFTPH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A922T	TCGA-09-2049	OV	TCGA	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation rewiring degron network	0.2778
p.A922T	TCGA-09-2049	OV	TCGA	PSTSS	DEG_SPOP_SBC_1	926:930	Mutation rewiring degron network	0.2222
p.A922T	DO29488	OV	ICGC	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation rewiring degron network	0.2778
p.A922T	DO29488	OV	ICGC	PSTSS	DEG_SPOP_SBC_1	926:930	Mutation rewiring degron network	0.2222
p.D613H	TCGA-63-5131	LUSC	TCGA	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation rewiring degron network	0.2222
p.D613H	DO26898	LUSC	ICGC	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation rewiring degron network	0.2222
p.S10C	TCGA-75-6214	LUAD	TCGA	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.7541
p.S10C	DO24830	LUAD	ICGC	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.7541
p.S929R	TCGA-A2-A0EQ	BRCA	TCGA	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation altering degron motif	0.7427
p.S929R	TCGA-A2-A0EQ	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	926:930	Mutation altering degron motif	0.7427
p.S929R	DO4773	BRCA	ICGC	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation altering degron motif	0.7427
p.S929R	DO4773	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	926:930	Mutation altering degron motif	0.7427
p.S929R	SIDM00068	Colorectal Carcinoma	GDSC	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation altering degron motif	0.7427
p.S929R	SIDM00068	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	926:930	Mutation altering degron motif	0.7427
p.S929R	SIDM00720	Mesothelioma	GDSC	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation altering degron motif	0.7427
p.S929R	SIDM00720	Mesothelioma	GDSC	PSTSS	DEG_SPOP_SBC_1	926:930	Mutation altering degron motif	0.7427
p.R7Q	TCGA-AG-A002	READ	TCGA	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.6218
p.R7Q	TCGA-EO-A22X	UCEC	TCGA	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.6218
p.R7Q	TCGA-EO-A3B0	UCEC	TCGA	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.6218
p.R7Q	DO219773	UCEC	ICGC	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.6218
p.R7Q	DO43907	UCEC	ICGC	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.6218
p.T620M	TCGA-AJ-A5DW	UCEC	TCGA	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation altering degron motif	0.7423
p.T620M	DO50075	UCEC	ICGC	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation altering degron motif	0.7423
p.I6M	TCGA-BR-6452	STAD	TCGA	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.6507
p.I6M	DO38404	STAD	ICGC	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.6507
p.T925P	TCGA-F5-6814	READ	TCGA	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation altering degron motif	0.8142
p.T925P	DO36556	READ	ICGC	LTPSTS	DEG_SCF_FBW7_1	924:929	Mutation altering degron motif	0.8142
p.D23N	DO224985	BRCA	ICGC	DIIRMYSSSP	CBL_PTK	4:13	Mutation rewiring degron network	0.0556
p.Y9C	DO222755	COCA	ICGC	DIIRMYSSSP	CBL_PTK	4:13	Mutation altering degron motif	0.7087
p.G635V	DO229045	LICA	ICGC	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation rewiring degron network	0.0833
p.T614I	DO232224	PBCA	ICGC	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation blocking phosphorylation signal	0.6944
p.P624L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation altering degron motif	0.7582
p.P624L	ACH-000951	Lung Cancer	CCLE	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation altering degron motif	0.7582
p.P624L	NCI-H2342	lung	COSMIC	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation altering degron motif	0.7582
p.H636R	SIDM01450	Gastric Carcinoma	GDSC	TPKTHSVPSA	DEG_COP1_1	617:626	Mutation rewiring degron network	0.0556

Kaplan plot for AFTPH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFTPH

UniProt ID: Q6ULP2

Entrez ID: 54812

Protein name: Aftiphilin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AFTPH in