DegronMD

Uniprot ID: Q6ULP2

Source protein: Aftiphilin

Source gene: AFTPH

Class: DEG_SCF_FBW7_1

Location: 924:929

E3 ligase: FBXW7

DEGRON score: 0.9937

ASA_SCORE: 71.95

COIL: 0.8462

CONS_SCORE: 0.6057

DSS_SCORE: 0.4978

HELIX: 0.0433

FCONS_SCORE: 0.987

RIG_SCORE: 0.6949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A922T	TCGA-09-2049	OV	TCGA	LTPSTS	DEG_SCF_FBW7_1	0.2778
p.A922T	DO29488	OV	ICGC	LTPSTS	DEG_SCF_FBW7_1	0.2778
p.S929R	TCGA-A2-A0EQ	BRCA	TCGA	LTPSTS	DEG_SCF_FBW7_1	0.7427
p.S929R	DO4773	BRCA	ICGC	LTPSTS	DEG_SCF_FBW7_1	0.7427
p.S929R	SIDM00068	Colorectal Carcinoma	GDSC	LTPSTS	DEG_SCF_FBW7_1	0.7427
p.S929R	SIDM00720	Mesothelioma	GDSC	LTPSTS	DEG_SCF_FBW7_1	0.7427
p.T925P	TCGA-F5-6814	READ	TCGA	LTPSTS	DEG_SCF_FBW7_1	0.8142
p.T925P	DO36556	READ	ICGC	LTPSTS	DEG_SCF_FBW7_1	0.8142

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ULP2	Aftiphilin	DEG_SCF_FBW7_1	924:929	LTPSTS	FBXW7	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons