DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DIIRMYSSSP
Uniprot ID:
Q6ULP2
Source protein:
Aftiphilin
Source gene:
AFTPH
Class:
CBL_PTK
Location:
4:13
E3 ligase:
CBL
DEGRON score:
0.694
ASA_SCORE:
57.95
COIL:
0.644
CONS_SCORE:
0.625
DSS_SCORE:
0.8112
HELIX:
0.0141
FCONS_SCORE:
0.8832
RIG_SCORE:
0.6958
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S10C
TCGA-75-6214
LUAD
TCGA
DIIRMYSSSP
CBL_PTK
0.7541
p.S10C
DO24830
LUAD
ICGC
DIIRMYSSSP
CBL_PTK
0.7541
p.R7Q
TCGA-AG-A002
READ
TCGA
DIIRMYSSSP
CBL_PTK
0.6218
p.R7Q
TCGA-EO-A22X
UCEC
TCGA
DIIRMYSSSP
CBL_PTK
0.6218
p.R7Q
TCGA-EO-A3B0
UCEC
TCGA
DIIRMYSSSP
CBL_PTK
0.6218
p.R7Q
DO219773
UCEC
ICGC
DIIRMYSSSP
CBL_PTK
0.6218
p.R7Q
DO43907
UCEC
ICGC
DIIRMYSSSP
CBL_PTK
0.6218
p.I6M
TCGA-BR-6452
STAD
TCGA
DIIRMYSSSP
CBL_PTK
0.6507
p.I6M
DO38404
STAD
ICGC
DIIRMYSSSP
CBL_PTK
0.6507
p.D23N
DO224985
BRCA
ICGC
DIIRMYSSSP
CBL_PTK
0.0556
p.Y9C
DO222755
COCA
ICGC
DIIRMYSSSP
CBL_PTK
0.7087
Drug responses associated with AFTPH mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DIIRMYSSSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ULP2
Aftiphilin
CBL_PTK
4:13
DIIRMYSSSP
CBL
0.694
More...
