DegronMD

Uniprot ID: Q6ULP2

Source protein: Aftiphilin

Source gene: AFTPH

Class: DEG_COP1_1

Location: 617:626

E3 ligase: COP1

DEGRON score: 0.9926

ASA_SCORE: 80.21

COIL: 0.8386

CONS_SCORE: 0.4096

DSS_SCORE: 0.7031

HELIX: 0.0891

FCONS_SCORE: 1.0239

RIG_SCORE: 0.6184

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D613H	TCGA-63-5131	LUSC	TCGA	TPKTHSVPSA	DEG_COP1_1	0.2222
p.D613H	DO26898	LUSC	ICGC	TPKTHSVPSA	DEG_COP1_1	0.2222
p.T620M	TCGA-AJ-A5DW	UCEC	TCGA	TPKTHSVPSA	DEG_COP1_1	0.7423
p.T620M	DO50075	UCEC	ICGC	TPKTHSVPSA	DEG_COP1_1	0.7423
p.G635V	DO229045	LICA	ICGC	TPKTHSVPSA	DEG_COP1_1	0.0833
p.T614I	DO232224	PBCA	ICGC	TPKTHSVPSA	DEG_COP1_1	0.6944
p.P624L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TPKTHSVPSA	DEG_COP1_1	0.7582
p.P624L	ACH-000951	Lung Cancer	CCLE	TPKTHSVPSA	DEG_COP1_1	0.7582
p.P624L	NCI-H2342	lung	COSMIC	TPKTHSVPSA	DEG_COP1_1	0.7582
p.H636R	SIDM01450	Gastric Carcinoma	GDSC	TPKTHSVPSA	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ULP2	Aftiphilin	DEG_COP1_1	617:626	TPKTHSVPSA	COP1	0.9926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons