DegronMD - Q8WWQ0(PHIP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1781N	TCGA-19-5956	GBM	TCGA	RQLLFED	LIG_APCC_ABBAyCdc20_2	1788:1794	Mutation rewiring degron network	0.1389
p.D1781N	DO13863	GBM	ICGC	RQLLFED	LIG_APCC_ABBAyCdc20_2	1788:1794	Mutation rewiring degron network	0.1389
p.V771A	TCGA-20-1685	OV	TCGA	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.2222
p.V771A	DO29688	OV	ICGC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.2222
p.S1522F	TCGA-2J-AABE	PAAD	TCGA	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation altering degron motif	0.7982
p.S1522F	DO51660	PAAD	ICGC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation altering degron motif	0.7982
p.R1711C	TCGA-AA-A010	COAD	TCGA	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation altering degron motif	0.8301
p.R797H	TCGA-AA-A010	COAD	TCGA	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.1944
p.R797H	DO229389	BTCA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.1944
p.S881L	TCGA-AB-2808	LAML	TCGA	AESSS	DEG_SPOP_SBC_1	877:881	Mutation altering degron motif	0.8778
p.S881L	DO21487	LAML	ICGC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation altering degron motif	0.8778
p.K1528N	TCGA-AG-A002	READ	TCGA	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation blocking ubiquitination signal	0.6944
p.K1528N	TCGA-D1-A16X	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation blocking ubiquitination signal	0.6944
p.K1528N	DO41799	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation blocking ubiquitination signal	0.6944
p.E1287D	TCGA-AP-A0LM	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.1667
p.E1287D	DO43306	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.1667
p.Q1707H	TCGA-AP-A1DV	UCEC	TCGA	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation altering degron motif	0.7582
p.Q1707H	DO43186	UCEC	ICGC	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation altering degron motif	0.7582
p.R1298Q	TCGA-AX-A05Z	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.R1298Q	TCGA-WE-AAA0	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.R1298Q	DO51294	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.R1298Q	DO40884	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.K767N	TCGA-AX-A05Z	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation altering degron motif	0.5806
p.K767N	DO40884	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation altering degron motif	0.5806
p.A978T	TCGA-AX-A2HC	UCEC	TCGA	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.25
p.A978T	DO41572	UCEC	ICGC	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.25
p.E976K	TCGA-B5-A11E	UCEC	TCGA	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.1944
p.E976K	TCGA-BK-A6W3	UCEC	TCGA	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.1944
p.E976K	DO228971	LICA	ICGC	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.1944
p.E976K	DO229054	LICA	ICGC	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.1944
p.E976K	DO50076	UCEC	ICGC	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.1944
p.E976K	DO41644	UCEC	ICGC	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.1944
p.R1718M	TCGA-B5-A1MR	UCEC	TCGA	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation rewiring degron network	0.2222
p.R1718M	DO41758	UCEC	ICGC	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation rewiring degron network	0.2222
p.H775Y	TCGA-B5-A3FC	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.1111
p.H775Y	DO41871	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.1111
p.A776T	TCGA-BH-A18G	BRCA	TCGA	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.0833
p.A776T	DO3686	BRCA	ICGC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.0833
p.G1569D	TCGA-BR-4362	STAD	TCGA	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1667
p.G1569D	DO38336	STAD	ICGC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1667
p.V1292M	TCGA-BS-A0UM	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.V1292M	DO43065	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.S1567T	TCGA-DK-A1A7	BLCA	TCGA	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1111
p.S1567T	DO483	BLCA	ICGC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1111
p.V1513A	TCGA-DU-6392	LGG	TCGA	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1111
p.V1513A	DO22237	LGG	ICGC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1111
p.K773E	TCGA-DU-6392	LGG	TCGA	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation blocking ubiquitination signal	0.6111
p.K773E	DO22237	LGG	ICGC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation blocking ubiquitination signal	0.6111
p.G1712V	TCGA-EE-A2GO	SKCM	TCGA	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation altering degron motif	0.7532
p.G1712V	DO37823	SKCM	ICGC	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation altering degron motif	0.7532
p.L1705V	TCGA-EI-6508	READ	TCGA	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation rewiring degron network	0.3056
p.L1705V	DO36389	READ	ICGC	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation rewiring degron network	0.3056
p.R1306I	TCGA-ER-A19N	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.0833
p.R1306I	DO37452	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.0833
p.E1519D	TCGA-F7-8489	HNSC	TCGA	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.2778
p.E1519D	DO14319	HNSC	ICGC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.2778
p.P806S	DO50483	BOCA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation altering degron motif	0.6752
p.P806S	SIDM00007	Other Solid Cancers	GDSC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation altering degron motif	0.6752
p.P806S	ACH-001550	Skin Cancer	CCLE	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation altering degron motif	0.6752
p.P806S	MCC13	skin	COSMIC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation altering degron motif	0.6752
p.H1568Y	DO227802	COCA	ICGC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1389
p.G1569A	DO222755	COCA	ICGC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1667
p.T874I	DO229005	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation rewiring degron network	0.25
p.T874I	DO230659	LAML	ICGC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation rewiring degron network	0.25
p.T874I	DO231140	LAML	ICGC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation rewiring degron network	0.25
p.T874I	DO228941	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation rewiring degron network	0.25
p.P1515L	DO233251	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1667
p.S1565T	DO233261	GACA	ICGC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation blocking phosphorylation signal	0.5
p.E811D	DO233697	GACA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.2778
p.D1704G	DO228664	LICA	ICGC	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation rewiring degron network	0.2778
p.D1514N	DO228998	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1389
p.L998I	DO229019	LICA	ICGC	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.0556
p.H794Q	DO229029	LICA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.1111
p.H794Q	DO229006	LICA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.1111
p.T798K	DO229041	LICA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.2222
p.P1716L	DO230525	LUSC	ICGC	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation rewiring degron network	0.2778
p.V975I	DO50679	ORCA	ICGC	NKIYSINP	CBL_PTK	981:988	Mutation rewiring degron network	0.1667
p.S809L	DO51496	PACA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation altering degron motif	0.7667
p.I812T	DO232959	PEME	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.25
p.S1283T	DO229268	THCA	ICGC	PGTST	DEG_SPOP_SBC_1	1293:1297	Mutation blocking phosphorylation signal	0.5
p.E803G	DO229232	THCA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation altering degron motif	0.6087
p.K891E	DO229232	THCA	ICGC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation substituting flanking lysine	0.1667
p.K889N	SIDM02018	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation substituting flanking lysine	0.2222
p.P769H	SIDM00660	Colorectal Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.2778
p.P769H	ACH-000985	Colon/Colorectal Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.2778
p.P769H	LS-411N	large intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.2778
p.P1584S	SIDM00596	Endometrial Carcinoma	GDSC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1944
p.P1584S	ACH-001517	Endometrial/Uterine Cancer	CCLE	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1944
p.P1584S	HEC-1	endometrium	COSMIC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1944
p.V1517I	SIDM00596	Endometrial Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.2222
p.V1517I	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.2222
p.V1517I	HEC-1	endometrium	COSMIC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.2222
p.R1587H	SIDM00498	Colorectal Carcinoma	GDSC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1111
p.R1587H	ACH-000970	Colon/Colorectal Cancer	CCLE	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1111
p.R1587H	SNU-C5	large intestine	COSMIC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation rewiring degron network	0.1111
p.V1513I	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1111
p.V1513I	ACH-002393	Lymphoma	CCLE	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1111
p.V1513I	CRO-AP3	NS	COSMIC	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1111
p.N987D	SIDM00537	Colorectal Carcinoma	GDSC	NKIYSINP	CBL_PTK	981:988	Mutation altering degron motif	0.5821
p.N987D	ACH-000982	Colon/Colorectal Cancer	CCLE	NKIYSINP	CBL_PTK	981:988	Mutation altering degron motif	0.5821
p.N987D	ACH-001345	Colon/Colorectal Cancer	CCLE	NKIYSINP	CBL_PTK	981:988	Mutation altering degron motif	0.5821
p.N987D	GP5d	large intestine	COSMIC	NKIYSINP	CBL_PTK	981:988	Mutation altering degron motif	0.5821
p.I768V	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.3056
p.I768V	ACH-000916	Lung Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.3056
p.I768V	NCI-H1573	lung	COSMIC	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation rewiring degron network	0.3056
p.S879G	SIDM01320	Pancreatic Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	877:881	Mutation altering degron motif	0.8104
p.S879G	ACH-000468	Pancreatic Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	877:881	Mutation altering degron motif	0.8104
p.K1586R	SIDM01611	Endometrial Carcinoma	GDSC	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation substituting flanking lysine	0.25
p.K1586R	ACH-000996	Endometrial/Uterine Cancer	CCLE	AKENM	DEG_APCC_KENBOX_2	1575:1579	Mutation substituting flanking lysine	0.25
p.S1522C	ACH-000385	Kidney Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	1521:1525	Mutation altering degron motif	0.7541
p.E1793K	ACH-001377	Pancreatic Cancer	CCLE	RQLLFED	LIG_APCC_ABBAyCdc20_2	1788:1794	Mutation altering degron motif	0.591
p.Q1723P	ACH-001611	Brain Cancer	CCLE	LQKKNRGGR	SCF_FBXL2	1706:1714	Mutation rewiring degron network	0.0833
p.K758T	ACH-001991	Primary	CCLE	PKENK	DEG_APCC_KENBOX_2	763:767	Mutation substituting flanking lysine	0.3056
p.R799S	ACH-002027	Endometrial/Uterine Cancer	CCLE	LEETPRPS	DEG_SCF_FBW7_1	802:809	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHIP

UniProt ID: Q8WWQ0

Entrez ID: 55023

Protein name: PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHIP in