DegronMD

Uniprot ID: Q8WWQ0

Source protein: PH-interacting protein

Source gene: PHIP

Class: LIG_APCC_ABBAyCdc20_2

Location: 1788:1794

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8364

ASA_SCORE: 114.2429

COIL: 0.5434

CONS_SCORE: 0.2838

DSS_SCORE: 0.5021

HELIX: 0.4344

FCONS_SCORE: 0.833

RIG_SCORE: 0.8105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1781N	TCGA-19-5956	GBM	TCGA	RQLLFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.D1781N	DO13863	GBM	ICGC	RQLLFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.E1793K	ACH-001377	Pancreatic Cancer	CCLE	RQLLFED	LIG_APCC_ABBAyCdc20_2	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWQ0	PH-interacting protein	LIG_APCC_ABBAyCdc20_2	1788:1794	RQLLFED	APC,CDC20,FZR1	0.8364	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons