DegronMD

Uniprot ID: Q8WWQ0

Source protein: PH-interacting protein

Source gene: PHIP

Class: DEG_SCF_FBW7_1

Location: 802:809

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 101.725

COIL: 0.8253

CONS_SCORE: 0.3133

DSS_SCORE: 0.7264

HELIX: 0.159

FCONS_SCORE: 1.0061

RIG_SCORE: 0.6487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R797H	TCGA-AA-A010	COAD	TCGA	LEETPRPS	DEG_SCF_FBW7_1	0.1944
p.R797H	DO229389	BTCA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.1944
p.P806S	DO50483	BOCA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.6752
p.P806S	SIDM00007	Other Solid Cancers	GDSC	LEETPRPS	DEG_SCF_FBW7_1	0.6752
p.P806S	ACH-001550	Skin Cancer	CCLE	LEETPRPS	DEG_SCF_FBW7_1	0.6752
p.P806S	MCC13	skin	COSMIC	LEETPRPS	DEG_SCF_FBW7_1	0.6752
p.E811D	DO233697	GACA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.2778
p.H794Q	DO229029	LICA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.1111
p.H794Q	DO229006	LICA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.1111
p.T798K	DO229041	LICA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.2222
p.S809L	DO51496	PACA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.7667
p.I812T	DO232959	PEME	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.25
p.E803G	DO229232	THCA	ICGC	LEETPRPS	DEG_SCF_FBW7_1	0.6087
p.R799S	ACH-002027	Endometrial/Uterine Cancer	CCLE	LEETPRPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWQ0	PH-interacting protein	DEG_SCF_FBW7_1	802:809	LEETPRPS	FBXW7	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons