DegronMD

Uniprot ID: Q8WWQ0

Source protein: PH-interacting protein

Source gene: PHIP

Class: DEG_APCC_KENBOX_2

Location: 1575:1579

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7315

ASA_SCORE: 103.28

COIL: 0.4662

CONS_SCORE: 0.274

DSS_SCORE: 0.7313

HELIX: 0.5214

FCONS_SCORE: 0.9731

RIG_SCORE: 0.6303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1569D	TCGA-BR-4362	STAD	TCGA	AKENM	DEG_APCC_KENBOX_2	0.1667
p.G1569D	DO38336	STAD	ICGC	AKENM	DEG_APCC_KENBOX_2	0.1667
p.S1567T	TCGA-DK-A1A7	BLCA	TCGA	AKENM	DEG_APCC_KENBOX_2	0.1111
p.S1567T	DO483	BLCA	ICGC	AKENM	DEG_APCC_KENBOX_2	0.1111
p.H1568Y	DO227802	COCA	ICGC	AKENM	DEG_APCC_KENBOX_2	0.1389
p.G1569A	DO222755	COCA	ICGC	AKENM	DEG_APCC_KENBOX_2	0.1667
p.S1565T	DO233261	GACA	ICGC	AKENM	DEG_APCC_KENBOX_2	0.5
p.P1584S	SIDM00596	Endometrial Carcinoma	GDSC	AKENM	DEG_APCC_KENBOX_2	0.1944
p.P1584S	ACH-001517	Endometrial/Uterine Cancer	CCLE	AKENM	DEG_APCC_KENBOX_2	0.1944
p.P1584S	HEC-1	endometrium	COSMIC	AKENM	DEG_APCC_KENBOX_2	0.1944
p.R1587H	SIDM00498	Colorectal Carcinoma	GDSC	AKENM	DEG_APCC_KENBOX_2	0.1111
p.R1587H	ACH-000970	Colon/Colorectal Cancer	CCLE	AKENM	DEG_APCC_KENBOX_2	0.1111
p.R1587H	SNU-C5	large_intestine	COSMIC	AKENM	DEG_APCC_KENBOX_2	0.1111
p.K1586R	SIDM01611	Endometrial Carcinoma	GDSC	AKENM	DEG_APCC_KENBOX_2	0.25
p.K1586R	ACH-000996	Endometrial/Uterine Cancer	CCLE	AKENM	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	1575:1579	AKENM	APC,CDC20,FZR1	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons