DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
NKIYSINP
Uniprot ID:
Q8WWQ0
Source protein:
PH-interacting protein
Source gene:
PHIP
Class:
CBL_PTK
Location:
981:988
E3 ligase:
CBL
DEGRON score:
0.8746
ASA_SCORE:
71.3125
COIL:
0.8265
CONS_SCORE:
0.3126
DSS_SCORE:
0.3094
HELIX:
0.073
FCONS_SCORE:
0.7597
RIG_SCORE:
0.7864
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A978T
TCGA-AX-A2HC
UCEC
TCGA
NKIYSINP
CBL_PTK
0.25
p.A978T
DO41572
UCEC
ICGC
NKIYSINP
CBL_PTK
0.25
p.E976K
TCGA-B5-A11E
UCEC
TCGA
NKIYSINP
CBL_PTK
0.1944
p.E976K
TCGA-BK-A6W3
UCEC
TCGA
NKIYSINP
CBL_PTK
0.1944
p.E976K
DO228971
LICA
ICGC
NKIYSINP
CBL_PTK
0.1944
p.E976K
DO229054
LICA
ICGC
NKIYSINP
CBL_PTK
0.1944
p.E976K
DO50076
UCEC
ICGC
NKIYSINP
CBL_PTK
0.1944
p.E976K
DO41644
UCEC
ICGC
NKIYSINP
CBL_PTK
0.1944
p.L998I
DO229019
LICA
ICGC
NKIYSINP
CBL_PTK
0.0556
p.V975I
DO50679
ORCA
ICGC
NKIYSINP
CBL_PTK
0.1667
p.N987D
SIDM00537
Colorectal Carcinoma
GDSC
NKIYSINP
CBL_PTK
0.5821
p.N987D
ACH-000982
Colon/Colorectal Cancer
CCLE
NKIYSINP
CBL_PTK
0.5821
p.N987D
ACH-001345
Colon/Colorectal Cancer
CCLE
NKIYSINP
CBL_PTK
0.5821
p.N987D
GP5d
large_intestine
COSMIC
NKIYSINP
CBL_PTK
0.5821
Drug responses associated with PHIP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKIYSINP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WWQ0
PH-interacting protein
CBL_PTK
981:988
NKIYSINP
CBL
0.8746
More...
