DegronMD

Uniprot ID: Q8WWQ0

Source protein: PH-interacting protein

Source gene: PHIP

Class: SCF_FBXL2

Location: 1706:1714

E3 ligase: FBXL2

DEGRON score: 0.9107

ASA_SCORE: 115.4778

COIL: 0.7798

CONS_SCORE: 0.3037

DSS_SCORE: 0.679

HELIX: 0.179

FCONS_SCORE: 1.0439

RIG_SCORE: 0.6938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1711C	TCGA-AA-A010	COAD	TCGA	LQKKNRGGR	SCF_FBXL2	0.8301
p.Q1707H	TCGA-AP-A1DV	UCEC	TCGA	LQKKNRGGR	SCF_FBXL2	0.7582
p.Q1707H	DO43186	UCEC	ICGC	LQKKNRGGR	SCF_FBXL2	0.7582
p.R1718M	TCGA-B5-A1MR	UCEC	TCGA	LQKKNRGGR	SCF_FBXL2	0.2222
p.R1718M	DO41758	UCEC	ICGC	LQKKNRGGR	SCF_FBXL2	0.2222
p.G1712V	TCGA-EE-A2GO	SKCM	TCGA	LQKKNRGGR	SCF_FBXL2	0.7532
p.G1712V	DO37823	SKCM	ICGC	LQKKNRGGR	SCF_FBXL2	0.7532
p.L1705V	TCGA-EI-6508	READ	TCGA	LQKKNRGGR	SCF_FBXL2	0.3056
p.L1705V	DO36389	READ	ICGC	LQKKNRGGR	SCF_FBXL2	0.3056
p.D1704G	DO228664	LICA	ICGC	LQKKNRGGR	SCF_FBXL2	0.2778
p.P1716L	DO230525	LUSC	ICGC	LQKKNRGGR	SCF_FBXL2	0.2778
p.Q1723P	ACH-001611	Brain Cancer	CCLE	LQKKNRGGR	SCF_FBXL2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWQ0	PH-interacting protein	SCF_FBXL2	1706:1714	LQKKNRGGR	FBXL2	0.9107	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons