DegronMD - Q13620(CUL4B)

FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239, PubMed:22118460). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:29779948, PubMed:22118460). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}. View more >>

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V105D	TCGA-55-8097	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1944
p.V105D	DO25699	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1944
p.D895G	TCGA-A5-A2K5	UCEC	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.1389
p.D895G	DO41379	UCEC	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.1389
p.D895N	TCGA-A8-A09G	BRCA	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.1389
p.D895N	DO1990	BRCA	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.1389
p.S892Y	TCGA-AP-A1E0	UCEC	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation blocking phosphorylation signal	0.5
p.S892Y	TCGA-BK-A6W3	UCEC	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation blocking phosphorylation signal	0.5
p.S892Y	DO50076	UCEC	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation blocking phosphorylation signal	0.5
p.S892Y	DO43154	UCEC	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation blocking phosphorylation signal	0.5
p.E900K	TCGA-CV-6955	HNSC	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.2778
p.E900K	DO14338	HNSC	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.2778
p.S93L	TCGA-D1-A17Q	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.S93L	DO41903	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.Y898C	TCGA-G4-6304	COAD	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation blocking phosphorylation signal	0.6667
p.Y898C	DO10639	COAD	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation blocking phosphorylation signal	0.6667
p.D895A	TCGA-JY-A93E	ESCA	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.1389
p.S110Y	TCGA-VS-A9U7	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.S110Y	DO219729	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.P906L	TCGA-YD-A9TB	SKCM	TCGA	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation altering degron motif	0.6471
p.P906L	DO51297	SKCM	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation altering degron motif	0.6471
p.S110F	TCGA-ZF-AA4V	BLCA	TCGA	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.S110F	DO219087	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.R901T	DO225215	BRCA	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.3056
p.R901T	DO227836	BRCA	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.3056
p.A109S	DO5745	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0833
p.P906T	DO228976	LICA	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation altering degron motif	0.5919
p.D897E	DO229024	LICA	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.1944
p.N907K	DO229038	LICA	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.3056
p.M899I	DO229470	SKCA	ICGC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.25
p.P96H	DO229211	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7694
p.L893F	SIDM00845	Burkitt's Lymphoma	GDSC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.0833
p.L893F	SIDM01519	Head and Neck Carcinoma	GDSC	DKENP	DEG_APCC_KENBOX_2	902:906	Mutation rewiring degron network	0.0833
p.P96S	SIDM00007	Other Solid Cancers	GDSC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6752
p.P96S	MCC13	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6752
p.S99L	SIDM00923	Cervical Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7667
p.S99L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7667
p.S99L	NCI-H1573	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7667
p.S99L	Ca-Ski	cervix	COSMIC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7667
p.S86L	Ca-Ski	cervix	COSMIC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.S86L	NCI-H1573	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556

Kaplan plot for CUL4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CUL4B

UniProt ID: Q13620

Entrez ID: 8450

Protein name: Cullin-4B (CUL-4B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CUL4B in