DegronMD

Uniprot ID: Q13620

Source protein: Cullin-4B

Source gene: CUL4B

Class: DEG_APCC_KENBOX_2

Location: 902:906

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6951

ASA_SCORE: 103.46

COIL: 0.9454

CONS_SCORE: 0.4416

DSS_SCORE: 0.5111

HELIX: 0.0514

FCONS_SCORE: 0.6924

RIG_SCORE: 0.7182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D895G	TCGA-A5-A2K5	UCEC	TCGA	DKENP	DEG_APCC_KENBOX_2	0.1389
p.D895G	DO41379	UCEC	ICGC	DKENP	DEG_APCC_KENBOX_2	0.1389
p.D895N	TCGA-A8-A09G	BRCA	TCGA	DKENP	DEG_APCC_KENBOX_2	0.1389
p.D895N	DO1990	BRCA	ICGC	DKENP	DEG_APCC_KENBOX_2	0.1389
p.S892Y	TCGA-AP-A1E0	UCEC	TCGA	DKENP	DEG_APCC_KENBOX_2	0.5
p.S892Y	TCGA-BK-A6W3	UCEC	TCGA	DKENP	DEG_APCC_KENBOX_2	0.5
p.S892Y	DO50076	UCEC	ICGC	DKENP	DEG_APCC_KENBOX_2	0.5
p.S892Y	DO43154	UCEC	ICGC	DKENP	DEG_APCC_KENBOX_2	0.5
p.E900K	TCGA-CV-6955	HNSC	TCGA	DKENP	DEG_APCC_KENBOX_2	0.2778
p.E900K	DO14338	HNSC	ICGC	DKENP	DEG_APCC_KENBOX_2	0.2778
p.Y898C	TCGA-G4-6304	COAD	TCGA	DKENP	DEG_APCC_KENBOX_2	0.6667
p.Y898C	DO10639	COAD	ICGC	DKENP	DEG_APCC_KENBOX_2	0.6667
p.D895A	TCGA-JY-A93E	ESCA	TCGA	DKENP	DEG_APCC_KENBOX_2	0.1389
p.P906L	TCGA-YD-A9TB	SKCM	TCGA	DKENP	DEG_APCC_KENBOX_2	0.6471
p.P906L	DO51297	SKCM	ICGC	DKENP	DEG_APCC_KENBOX_2	0.6471
p.R901T	DO225215	BRCA	ICGC	DKENP	DEG_APCC_KENBOX_2	0.3056
p.R901T	DO227836	BRCA	ICGC	DKENP	DEG_APCC_KENBOX_2	0.3056
p.P906T	DO228976	LICA	ICGC	DKENP	DEG_APCC_KENBOX_2	0.5919
p.D897E	DO229024	LICA	ICGC	DKENP	DEG_APCC_KENBOX_2	0.1944
p.N907K	DO229038	LICA	ICGC	DKENP	DEG_APCC_KENBOX_2	0.3056
p.M899I	DO229470	SKCA	ICGC	DKENP	DEG_APCC_KENBOX_2	0.25
p.L893F	SIDM00845	Burkitt's Lymphoma	GDSC	DKENP	DEG_APCC_KENBOX_2	0.0833
p.L893F	SIDM01519	Head and Neck Carcinoma	GDSC	DKENP	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13620	Cullin-4B	DEG_APCC_KENBOX_2	902:906	DKENP	APC,CDC20,FZR1	0.6951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons