DegronMD - P35226(BMI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S274T	TCGA-98-A538	LUSC	TCGA	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation blocking phosphorylation signal	0.75
p.S274T	TCGA-98-A538	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.6667
p.S274T	DO219177	LUSC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation blocking phosphorylation signal	0.75
p.S274T	DO219177	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.6667
p.S269F	TCGA-AX-A06F	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.9093
p.S269F	DO41752	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.9093
p.A258V	TCGA-BR-4201	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.A258V	DO38707	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.D256N	TCGA-D1-A101	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.D256N	DO43955	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.P278S	TCGA-EE-A2A0	SKCM	TCGA	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation altering degron motif	0.6752
p.P278S	DO37439	SKCM	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation altering degron motif	0.6752
p.V279L	TCGA-EE-A2GN	SKCM	TCGA	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation altering degron motif	0.5654
p.V279L	DO37896	SKCM	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation altering degron motif	0.5654
p.Q280P	DO227507	BRCA	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation altering degron motif	0.5924
p.H283Y	DO44400	CESC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.2778
p.D256G	DO222762	COCA	ICGC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.P282T	DO15703	HNSC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.3056
p.H288Y	DO52086	HNSC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.1389
p.P282S	DO45096	LIRI	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.3056
p.I289F	DO45346	LUAD	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.1111
p.P278T	DO232224	PBCA	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation altering degron motif	0.7031
p.S291R	DO41572	UCEC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.0556
p.I265V	SIDM00845	Burkitt's Lymphoma	GDSC	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.0556
p.I265V	SIDM00845	Burkitt's Lymphoma	GDSC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.I265V	ACH-000992	Head and Neck Cancer	CCLE	PSTPVQS	DEG_SCF_FBW7_1	275:281	Mutation rewiring degron network	0.0556
p.I265V	ACH-000992	Head and Neck Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.D256Y	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.D256Y	ACH-000837	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.D256Y	NCI-H322M	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.G264V	ACH-001649	Prostate Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.2778

Kaplan plot for BMI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMI1

UniProt ID: P35226

Entrez ID: 100532731

Protein name: Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMI1 in