DegronMD

Uniprot ID: P35226

Source protein: Polycomb complex protein BMI-1

Source gene: BMI1

Class: DEG_SCF_FBW7_1

Location: 275:281

E3 ligase: FBXW7

DEGRON score: 0.9758

ASA_SCORE: 97.3429

COIL: 0.9636

CONS_SCORE: 0.3736

DSS_SCORE: 0.7076

HELIX: 0.0129

FCONS_SCORE: 0.9579

RIG_SCORE: 0.5352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S274T	TCGA-98-A538	LUSC	TCGA	PSTPVQS	DEG_SCF_FBW7_1	0.75
p.S274T	DO219177	LUSC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.75
p.P278S	TCGA-EE-A2A0	SKCM	TCGA	PSTPVQS	DEG_SCF_FBW7_1	0.6752
p.P278S	DO37439	SKCM	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.6752
p.V279L	TCGA-EE-A2GN	SKCM	TCGA	PSTPVQS	DEG_SCF_FBW7_1	0.5654
p.V279L	DO37896	SKCM	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.5654
p.Q280P	DO227507	BRCA	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.5924
p.H283Y	DO44400	CESC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.2778
p.P282T	DO15703	HNSC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.3056
p.H288Y	DO52086	HNSC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.1389
p.P282S	DO45096	LIRI	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.3056
p.I289F	DO45346	LUAD	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.1111
p.P278T	DO232224	PBCA	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.7031
p.S291R	DO41572	UCEC	ICGC	PSTPVQS	DEG_SCF_FBW7_1	0.0556
p.I265V	SIDM00845	Burkitt's Lymphoma	GDSC	PSTPVQS	DEG_SCF_FBW7_1	0.0556
p.I265V	ACH-000992	Head and Neck Cancer	CCLE	PSTPVQS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35226	Polycomb complex protein BMI-1	DEG_SCF_FBW7_1	275:281	PSTPVQS	FBXW7	0.9758	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons