DegronMD

Uniprot ID: Q2LD37

Source protein: Transmembrane protein KIAA1109

Source gene: KIAA1109

Class: DEG_APCC_DBOX_1

Location: 3624:3632

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9777

ASA_SCORE: 97.9667

COIL: 0.6902

CONS_SCORE: 0.3226

DSS_SCORE: 0.5915

HELIX: 0.2763

FCONS_SCORE: 0.9986

RIG_SCORE: 0.6422

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3616Q	TCGA-25-1329	OV	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	0.1111
p.R3616Q	DO31230	OV	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.1111
p.E3642K	TCGA-46-3765	LUSC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	0.0556
p.E3642K	DO26959	LUSC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.0556
p.A3622D	TCGA-AJ-A3EK	UCEC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	0.2778
p.A3622D	DO41584	UCEC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.2778
p.R3625K	TCGA-CN-4723	HNSC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	0.7237
p.R3625K	DO14830	HNSC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.7237
p.R3630Q	TCGA-DM-A1HB	COAD	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	0.6218
p.R3630Q	DO227844	COCA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.6218
p.S3619N	TCGA-EA-A3HS	CESC	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	0.6389
p.S3619N	DO6260	CESC	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.6389
p.S3621C	TCGA-XF-A9T5	BLCA	TCGA	GRPPLKRME	DEG_APCC_DBOX_1	0.25
p.S3621C	DO51925	BLCA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.25
p.M3631L	DO228740	GACA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.5999
p.A3622S	DO228974	LICA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.2778
p.V3638I	DO49460	PACA	ICGC	GRPPLKRME	DEG_APCC_DBOX_1	0.1667
p.V3638I	SIDM00845	Burkitt's Lymphoma	GDSC	GRPPLKRME	DEG_APCC_DBOX_1	0.1667
p.V3638I	SIDM01519	Head and Neck Carcinoma	GDSC	GRPPLKRME	DEG_APCC_DBOX_1	0.1667
p.E3642D	SIDM00845	Burkitt's Lymphoma	GDSC	GRPPLKRME	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2LD37	Transmembrane protein KIAA1109	DEG_APCC_DBOX_1	3624:3632	GRPPLKRME	APC,CDC20,FZR1	0.9777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons