DegronMD

Uniprot ID: Q9P1A6

Source protein: Disks large-associated protein 2

Source gene: DLGAP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 391:397

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9661

ASA_SCORE: 97.8286

COIL: 0.8133

CONS_SCORE: 0.3952

DSS_SCORE: 0.3983

HELIX: 0.1601

FCONS_SCORE: 0.761

RIG_SCORE: 0.761

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G392R	TCGA-29-1762	OV	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.7568
p.G392R	TCGA-BR-8078	STAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.7568
p.G392R	DO29136	OV	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.7568
p.G392R	DO38288	STAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.7568
p.A381E	TCGA-33-4566	LUSC	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A381E	DO26790	LUSC	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A381S	TCGA-64-1676	LUAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A381S	DO23629	LUAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P395L	TCGA-BR-8361	STAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.7582
p.P395L	DO48032	STAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.7582
p.H399R	TCGA-FI-A2D0	UCEC	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H399R	DO43891	UCEC	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E385G	TCGA-G4-6302	COAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E385G	DO8778	COAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q406R	TCGA-MX-A5UJ	STAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q406R	DO233871	GACA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q406R	DO48547	STAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P384Q	DO229010	COCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.P384Q	DO229013	COCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.P384Q	DO229003	COCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.P384Q	DO229489	LAML	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q402E	DO234334	ESAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L388P	DO229213	THCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.K392T	SIDM02050	Colorectal Carcinoma	GDSC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.7306
p.P401A	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Y404C	ACH-000156	Leukemia	CCLE	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Y404C	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P386L	ACH-000999	Colon/Colorectal Cancer	CCLE	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P386L	SNU-1040	large_intestine	COSMIC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q400L	EMC-BAC-2	lung	COSMIC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPLLHQD

Degron related mutations and impact score

Drug responses associated with DLGAP2 mutations

All proteins holding degron of KPLLHQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1A6	Disks large-associated protein 2	LIG_APCC_ABBAyCdc20_2	391:397	KPLLHQD	APC,CDC20,FZR1	0.9661	More...