DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DLDPQYSWSP
Uniprot ID:
Q9P1A6
Source protein:
Disks large-associated protein 2
Source gene:
DLGAP2
Class:
CBL_PTK
Location:
55:64
E3 ligase:
CBL
DEGRON score:
0.8602
ASA_SCORE:
71.96
COIL:
0.8558
CONS_SCORE:
0.2111
DSS_SCORE:
0.6981
HELIX:
0.115
FCONS_SCORE:
0.7417
RIG_SCORE:
0.68
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P57L
TCGA-32-2616
GBM
TCGA
DLDPQYSWSP
CBL_PTK
0.7582
p.P57L
DO13462
GBM
ICGC
DLDPQYSWSP
CBL_PTK
0.7582
p.S60L
TCGA-CV-7568
HNSC
TCGA
DLDPQYSWSP
CBL_PTK
0.7667
p.S60L
DO14160
HNSC
ICGC
DLDPQYSWSP
CBL_PTK
0.7667
p.A45T
TCGA-VQ-AA6D
STAD
TCGA
DLDPQYSWSP
CBL_PTK
0.0556
p.A45T
DO233885
GACA
ICGC
DLDPQYSWSP
CBL_PTK
0.0556
p.A45T
DO222392
STAD
ICGC
DLDPQYSWSP
CBL_PTK
0.0556
p.G50R
TCGA-WE-A8ZQ
SKCM
TCGA
DLDPQYSWSP
CBL_PTK
0.1944
p.G50R
DO51288
SKCM
ICGC
DLDPQYSWSP
CBL_PTK
0.1944
p.G50R
ACH-001624
Brain Cancer
CCLE
DLDPQYSWSP
CBL_PTK
0.1944
p.R58H
DO44096
COAD
ICGC
DLDPQYSWSP
CBL_PTK
0.8244
p.R54H
DO233193
GACA
ICGC
DLDPQYSWSP
CBL_PTK
0.3056
p.R54H
ACH-000979
Prostate Cancer
CCLE
DLDPQYSWSP
CBL_PTK
0.3056
p.G51E
DO220895
MELA
ICGC
DLDPQYSWSP
CBL_PTK
0.2222
p.R58C
DO229160
NKTL
ICGC
DLDPQYSWSP
CBL_PTK
0.8301
p.R52C
DO38404
STAD
ICGC
DLDPQYSWSP
CBL_PTK
0.25
p.R52C
ACH-000963
Colon/Colorectal Cancer
CCLE
DLDPQYSWSP
CBL_PTK
0.25
p.T66M
SIDM00933
Breast Carcinoma
GDSC
DLDPQYSWSP
CBL_PTK
0.2778
p.T66M
CAL-51
breast
COSMIC
DLDPQYSWSP
CBL_PTK
0.2778
p.D56N
SIDM00853
Other Sarcomas
GDSC
DLDPQYSWSP
CBL_PTK
0.6932
p.D56N
GCT
soft_tissue
COSMIC
DLDPQYSWSP
CBL_PTK
0.6932
p.R54S
ACH-000871
Lung Cancer
CCLE
DLDPQYSWSP
CBL_PTK
0.3056
p.C48F
ACH-001028
Rhabdoid
CCLE
DLDPQYSWSP
CBL_PTK
0.1389
p.T65M
CAL-51
breast
COSMIC
DLDPQYSWSP
CBL_PTK
0.3056
p.D55N
GCT
soft_tissue
COSMIC
DLDPQYSWSP
CBL_PTK
0.5821
Drug responses associated with DLGAP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLDPQYSWSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P1A6
Disks large-associated protein 2
CBL_PTK
55:64
DLDPQYSWSP
CBL
0.8602
More...