DegronMD

Uniprot ID: Q9P1A6

Source protein: Disks large-associated protein 2

Source gene: DLGAP2

Class: CBL_PTK

Location: 69:77

E3 ligase: CBL

DEGRON score: 0.9265

ASA_SCORE: 89.9222

COIL: 0.8404

CONS_SCORE: 0.3075

DSS_SCORE: 0.6306

HELIX: 0.1451

FCONS_SCORE: 0.8513

RIG_SCORE: 0.6768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H75Q	TCGA-55-8302	LUAD	TCGA	NEERYSPAP	CBL_PTK	0.7582
p.H75Q	DO45312	LUAD	ICGC	NEERYSPAP	CBL_PTK	0.7582
p.P82Q	TCGA-GF-A2C7	SKCM	TCGA	NEERYSPAP	CBL_PTK	0.1944
p.P82Q	DO37407	SKCM	ICGC	NEERYSPAP	CBL_PTK	0.1944
p.D74N	TCGA-HF-7132	STAD	TCGA	NEERYSPAP	CBL_PTK	0.6932
p.D74N	DO38214	STAD	ICGC	NEERYSPAP	CBL_PTK	0.6932
p.R83W	TCGA-HU-A4G8	STAD	TCGA	NEERYSPAP	CBL_PTK	0.1667
p.R83W	DO47819	STAD	ICGC	NEERYSPAP	CBL_PTK	0.1667
p.H85Q	TCGA-RQ-AAAT	DLBC	TCGA	NEERYSPAP	CBL_PTK	0.1111
p.H85Q	DO219924	DLBC	ICGC	NEERYSPAP	CBL_PTK	0.1111
p.P69L	DO220913	MELA	ICGC	NEERYSPAP	CBL_PTK	0.7582
p.T66M	SIDM00933	Breast Carcinoma	GDSC	NEERYSPAP	CBL_PTK	0.25
p.T66M	CAL-51	breast	COSMIC	NEERYSPAP	CBL_PTK	0.25
p.S75A	SIDM01263	T-Lymphoblastic Leukemia	GDSC	NEERYSPAP	CBL_PTK	0.87
p.G73C	ACH-000769	Lung Cancer	CCLE	NEERYSPAP	CBL_PTK	0.76
p.G73C	LK-2	lung	COSMIC	NEERYSPAP	CBL_PTK	0.76
p.R87W	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	NEERYSPAP	CBL_PTK	0.0556
p.T65M	CAL-51	breast	COSMIC	NEERYSPAP	CBL_PTK	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1A6	Disks large-associated protein 2	CBL_PTK	69:77	NEERYSPAP	CBL	0.9265	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons