DegronMD

Uniprot ID: Q9Y2H0

Source protein: Disks large-associated protein 4

Source gene: DLGAP4

Class: DEG_APCC_DBOX_1

Location: 412:420

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9941

ASA_SCORE: 97.3222

COIL: 0.7646

CONS_SCORE: 0.404

DSS_SCORE: 0.5784

HELIX: 0.2037

FCONS_SCORE: 1.0829

RIG_SCORE: 0.7038

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R418L	DO228976	LICA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.7316
p.K412T	HEC-1	endometrium	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	0.7306
p.R414C	DO51638	CESC	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.719
p.R414C	DO223541	CLLE	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.719
p.R418C	SIDM00801	Melanoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	0.719
p.R418C	A101D	skin	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	0.719
p.R418H	DO49952	CESC	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.7133
p.R414H	CCK-81	large_intestine	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	0.7133
p.L416M	SIDM01397	Melanoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	0.711
p.L416M	ACH-000765	Skin Cancer	CCLE	PRRSLDRLD	DEG_APCC_DBOX_1	0.711
p.D417G	SIDM00976	Melanoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	0.6087
p.D417G	ACH-002205	Skin Cancer	CCLE	PRRSLDRLD	DEG_APCC_DBOX_1	0.6087
p.D417G	WM1552C	skin	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	0.6087
p.N411S	TCGA-EE-A29D	SKCM	TCGA	PRRSLDRLD	DEG_APCC_DBOX_1	0.3056
p.N411S	DO38123	SKCM	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.3056
p.N411K	DO35116	PACA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.3056
p.A409T	DO233616	GACA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.25
p.A424S	DO229029	LICA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.2222
p.G407V	DO229148	THCA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.1944
p.L425M	SIDM00826	Colorectal Carcinoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	0.1944
p.L425M	ACH-001039	Colon/Colorectal Cancer	CCLE	PRRSLDRLD	DEG_APCC_DBOX_1	0.1944
p.L425M	COLO-205	large_intestine	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	0.1944
p.R426L	DO37421	SKCM	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.1667
p.A406V	LS-411N	large_intestine	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	0.1667
p.D404N	DO48020	STAD	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	0.1111

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Drug responses associated with DLGAP4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRRSLDRLD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H0	Disks large-associated protein 4	DEG_APCC_DBOX_1	412:420	PRRSLDRLD	APC,CDC20,FZR1	0.9941	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRRSLDRLD

Degron related mutations and impact score

Drug responses associated with DLGAP4 mutations

All proteins holding degron of PRRSLDRLD