DegronMD

Uniprot ID: Q9ULI3

Source protein: Protein HEG homolog 1

Source gene: HEG1

Class: DEG_SPOP_SBC_1

Location: 711:715

E3 ligase: SPOP

DEGRON score: 0.7294

ASA_SCORE: 91.84

COIL: 0.9348

CONS_SCORE: 0.3646

DSS_SCORE: 0.4889

HELIX: 0.0134

FCONS_SCORE: 0.9302

RIG_SCORE: 0.5969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L701V	TCGA-DR-A0ZM	CESC	TCGA	PWSSS	DEG_SPOP_SBC_1	0.0556
p.L701V	DO6254	CESC	ICGC	PWSSS	DEG_SPOP_SBC_1	0.0556
p.S714F	TCGA-EE-A2GI	SKCM	TCGA	PWSSS	DEG_SPOP_SBC_1	0.7982
p.S714F	DO37410	SKCM	ICGC	PWSSS	DEG_SPOP_SBC_1	0.7982
p.S722Y	TCGA-RC-A7SK	LIHC	TCGA	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S722Y	DO52314	LIHC	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S722F	DO222875	MELA	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S704Y	SIDM00520	Mesothelioma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S704Y	ACH-002134	Lung Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S704Y	H2818	pleura	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S713F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.7982
p.S713F	ACH-001362	Lung Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	0.7982
p.S713F	NCI-H1770	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15884	Transcription factor 4	DEG_SPOP_SBC_1	226:230	PWSSS	SPOP	0.9121	More...
Q9H6U6	BCAS3 microtubule associated cell migration factor	DEG_SPOP_SBC_1	385:389	PWSSS	SPOP	0.6204	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	711:715	PWSSS	SPOP	0.7294	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	518:522	PWSSS	SPOP	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons