DegronMD

Uniprot ID: Q9UPZ9

Source protein: Serine/threonine-protein kinase ICK

Source gene: CILK1

Class: DEG_SPOP_SBC_1

Location: 518:522

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 75.12

COIL: 0.862

CONS_SCORE: 0.3568

DSS_SCORE: 0.4886

HELIX: 0.0998

FCONS_SCORE: 1.0025

RIG_SCORE: 0.6652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P509S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.0833
p.P509S	SIDM00971	Breast Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15884	Transcription factor 4	DEG_SPOP_SBC_1	226:230	PWSSS	SPOP	0.9121	More...
Q9H6U6	BCAS3 microtubule associated cell migration factor	DEG_SPOP_SBC_1	385:389	PWSSS	SPOP	0.6204	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	711:715	PWSSS	SPOP	0.7294	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	518:522	PWSSS	SPOP	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons