DegronMD

Uniprot ID: P15884

Source protein: Transcription factor 4

Source gene: TCF4

Class: DEG_SPOP_SBC_1

Location: 226:230

E3 ligase: SPOP

DEGRON score: 0.9121

ASA_SCORE: 32.38

COIL: 0.8238

CONS_SCORE: 0.4461

DSS_SCORE: 0.6131

HELIX: 0.1038

FCONS_SCORE: 1.2074

RIG_SCORE: 0.5928

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L229F	TCGA-2Z-A9J3	KIRP	TCGA	PWSSS	DEG_SPOP_SBC_1	0.6981
p.G222V	TCGA-52-7809	LUSC	TCGA	PWSSS	DEG_SPOP_SBC_1	0.2222
p.G230V	TCGA-ER-A19P	SKCM	TCGA	PWSSS	DEG_SPOP_SBC_1	0.7532
p.P238T	TCGA-IB-7651	PAAD	TCGA	PWSSS	DEG_SPOP_SBC_1	0.1111
p.G239R	TCGA-NK-A5CT	LUSC	TCGA	PWSSS	DEG_SPOP_SBC_1	0.0833
p.L228F	TCGA-YG-AA3N	SKCM	TCGA	PWSSS	DEG_SPOP_SBC_1	0.6981
p.M217I	DO8360	COAD	ICGC	PWSSS	DEG_SPOP_SBC_1	0.0833
p.G237V	DO228627	GACA	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.G232A	DO233718	GACA	ICGC	PWSSS	DEG_SPOP_SBC_1	0.2778
p.S229H	DO222546	MELA	ICGC	PWSSS	DEG_SPOP_SBC_1	0.7609
p.G220S	DO37406	SKCM	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1667
p.Q235H	DO41133	UCEC	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1944
p.G222S	SIDM01659	Kidney Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.2222
p.L220F	SIDM01519	Head and Neck Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.1667
p.L220V	SIDM01519	Head and Neck Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.1667
p.G228R	ACH-000853	Lung Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	0.7568
p.G228R	NCI-H661	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7568
p.P222S	ACH-001190	Skin Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	0.2222
p.P222S	SK-MEL-2	skin	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.2222
p.P226L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7582
p.H222Q	huH-1	liver	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.2222
p.S231N	TE-10	oesophagus	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.3056
p.G218V	NCI-SNU-1	stomach	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1111
p.G236R	RPMI-2650	upper_aerodigestive_tract	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1667
p.P224L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.2778
p.P232L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.2778
p.T237K	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S228N	SNG-M	endometrium	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7069
p.G231V	NCI-SNU-1	stomach	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.3056
p.P219L	SNU-1040	large_intestine	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S227T	IST-MEL1	skin	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7116
p.H238R	CCK-81	large_intestine	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1111
p.P237L	SNU-1040	large_intestine	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.H228Q	huH-1	liver	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7582
p.P237A	NCI-H1869	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S227N	SNG-M	endometrium	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7069
p.S229N	TE-10	oesophagus	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7069
p.H220Q	huH-1	liver	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1667
p.N229D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.6932
p.T226K	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7306
p.S237N	TE-10	oesophagus	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.P219A	NCI-H1869	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1389
p.S226T	IST-MEL1	skin	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15884	Transcription factor 4	DEG_SPOP_SBC_1	226:230	PWSSS	SPOP	0.9121	More...
Q9H6U6	BCAS3 microtubule associated cell migration factor	DEG_SPOP_SBC_1	385:389	PWSSS	SPOP	0.6204	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	711:715	PWSSS	SPOP	0.7294	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	518:522	PWSSS	SPOP	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PWSSS

Degron related mutations and impact score

Drug responses associated with TCF4 mutations

All proteins holding degron of PWSSS