DegronMD

Uniprot ID: Q9H6U6

Source protein: BCAS3 microtubule associated cell migration factor

Source gene: BCAS3

Class: DEG_SPOP_SBC_1

Location: 385:389

E3 ligase: SPOP

DEGRON score: 0.6204

ASA_SCORE: 77.9

COIL: 0.859

CONS_SCORE: 0.396

DSS_SCORE: 0.0364

HELIX: 0.1

FCONS_SCORE: 0.6618

RIG_SCORE: 0.765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L382P	TCGA-FI-A2F4	UCEC	TCGA	PWSSS	DEG_SPOP_SBC_1	0.25
p.M382I	DO44027	BLCA	ICGC	PWSSS	DEG_SPOP_SBC_1	0.25
p.E380K	DO219038	BLCA	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1944
p.I394L	DO45317	LUAD	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1944
p.A391T	DO24692	LUAD	ICGC	PWSSS	DEG_SPOP_SBC_1	0.2778
p.L388R	DO27871	ORCA	ICGC	PWSSS	DEG_SPOP_SBC_1	0.8428
p.D397G	DO42023	UCEC	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1111
p.D397N	DO43755	UCEC	ICGC	PWSSS	DEG_SPOP_SBC_1	0.1111
p.H377Y	SIDM01039	Other Solid Cancers	GDSC	PWSSS	DEG_SPOP_SBC_1	0.1111
p.H377Y	ACH-001529	Endometrial/Uterine Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	0.1111
p.H377Y	JAR	placenta	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.1111
p.V393I	SIDM00282	Colorectal Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	0.2222
p.V393I	ACH-000998	Colon/Colorectal Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	0.2222
p.V393I	CW-2	large_intestine	COSMIC	PWSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15884	Transcription factor 4	DEG_SPOP_SBC_1	226:230	PWSSS	SPOP	0.9121	More...
Q9H6U6	BCAS3 microtubule associated cell migration factor	DEG_SPOP_SBC_1	385:389	PWSSS	SPOP	0.6204	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	711:715	PWSSS	SPOP	0.7294	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	518:522	PWSSS	SPOP	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons