DegronMD

Uniprot ID: Q9H8J5

Source protein: MANSC domain-containing protein 1

Source gene: MANSC1

Class: DEG_SPOP_SBC_1

Location: 346:350

E3 ligase: SPOP

DEGRON score: 0.9938

ASA_SCORE: 81.68

COIL: 0.8414

CONS_SCORE: 0.4937

DSS_SCORE: 0.4945

HELIX: 0.1122

FCONS_SCORE: 1.1836

RIG_SCORE: 0.7053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M343I	TCGA-28-1760	GBM	TCGA	VESST	DEG_SPOP_SBC_1	0.25
p.S348Y	TCGA-AJ-A3EL	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	0.712
p.T354A	TCGA-AZ-6598	COAD	TCGA	VESST	DEG_SPOP_SBC_1	0.2222
p.G359D	TCGA-B8-5550	KIRC	TCGA	VESST	DEG_SPOP_SBC_1	0.0833
p.T339A	TCGA-BR-4361	STAD	TCGA	VESST	DEG_SPOP_SBC_1	0.1389
p.Y341S	DO44115	BRCA	ICGC	VESST	DEG_SPOP_SBC_1	0.1944
p.D340G	DO50291	SKCM	ICGC	VESST	DEG_SPOP_SBC_1	0.1667
p.T350S	SIDM01162	Kidney Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	0.6005
p.T350S	SIDM01076	B-Lymphoblastic Leukemia	GDSC	VESST	DEG_SPOP_SBC_1	0.6005
p.T350S	ACH-000070	Leukemia	CCLE	VESST	DEG_SPOP_SBC_1	0.6005
p.T350S	ACH-001398	Kidney Cancer	CCLE	VESST	DEG_SPOP_SBC_1	0.6005
p.T350S	697	haematopoietic_and_lymphoid_tissue	COSMIC	VESST	DEG_SPOP_SBC_1	0.6005
p.T350S	SW156	kidney	COSMIC	VESST	DEG_SPOP_SBC_1	0.6005
p.A355V	SIDM01059	Melanoma	GDSC	VESST	DEG_SPOP_SBC_1	0.1944
p.Y341D	HT-115	large_intestine	COSMIC	VESST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	318:322	VESST	SPOP	0.9996	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	675:679	VESST	SPOP	0.842	More...
Q6R327	Rapamycin-insensitive companion of mTOR	DEG_SPOP_SBC_1	1205:1209	VESST	SPOP	0.9971	More...
Q6ZTR5	Cilia- and flagella-associated protein 47	DEG_SPOP_SBC_1	2013:2017	VESST	SPOP	0.7453	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	581:585	VESST	SPOP	0.9759	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	23:27	VESST	SPOP	0.9811	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	346:350	VESST	SPOP	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons