DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VESST
Uniprot ID:
Q6ZTR5
Source protein:
Cilia- and flagella-associated protein 47
Source gene:
CFAP47
Class:
DEG_SPOP_SBC_1
Location:
2013:2017
E3 ligase:
SPOP
DEGRON score:
0.7453
ASA_SCORE:
58.9
COIL:
0.4426
CONS_SCORE:
0
DSS_SCORE:
0.2653
HELIX:
0.0156
FCONS_SCORE:
0
RIG_SCORE:
0.798
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CFAP47 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VESST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O76039
Cyclin-dependent kinase-like 5
DEG_SPOP_SBC_1
318:322
VESST
SPOP
0.9996
More...
P49321
Nuclear autoantigenic sperm protein
DEG_SPOP_SBC_1
675:679
VESST
SPOP
0.842
More...
Q6R327
Rapamycin-insensitive companion of mTOR
DEG_SPOP_SBC_1
1205:1209
VESST
SPOP
0.9971
More...
Q6ZTR5
Cilia- and flagella-associated protein 47
DEG_SPOP_SBC_1
2013:2017
VESST
SPOP
0.7453
More...
Q9ULI3
Protein HEG homolog 1
DEG_SPOP_SBC_1
581:585
VESST
SPOP
0.9759
More...
Q9C0D7
Probable ribonuclease ZC3H12C
DEG_SPOP_SBC_1
23:27
VESST
SPOP
0.9811
More...
Q9H8J5
MANSC domain-containing protein 1
DEG_SPOP_SBC_1
346:350
VESST
SPOP
0.9938
More...