DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SPOP_SBC_1

Location: 1642:1646

E3 ligase: SPOP

DEGRON score: 0.996

ASA_SCORE: 76.8

COIL: 0.7038

CONS_SCORE: 0.7649

DSS_SCORE: 0.6504

HELIX: 0.0298

FCONS_SCORE: 0.9877

RIG_SCORE: 0.7011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1656K	TCGA-77-A5GB	LUSC	TCGA	VISTS	DEG_SPOP_SBC_1	0.0556
p.E1656K	DO45439	LUSC	ICGC	VISTS	DEG_SPOP_SBC_1	0.0556
p.T1637I	SIDM00555	Glioblastoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.1944
p.T1637I	ACH-000631	Brain Cancer	CCLE	VISTS	DEG_SPOP_SBC_1	0.1944
p.T1637I	KS-1	central_nervous_system	COSMIC	VISTS	DEG_SPOP_SBC_1	0.1944
p.G1650A	SIDM01190	Bladder Carcinoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.2222
p.G1650A	ACH-000720	Bladder Cancer	CCLE	VISTS	DEG_SPOP_SBC_1	0.2222
p.G1650A	TCCSUP	urinary_tract	COSMIC	VISTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2212:2216	VISTS	SPOP	0.6313	More...
P18583	Protein SON	DEG_SPOP_SBC_1	1642:1646	VISTS	SPOP	0.996	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	1680:1684	VISTS	SPOP	0.8674	More...
Q9UPS8	Ankyrin repeat domain-containing protein 26	DEG_SPOP_SBC_1	1632:1636	VISTS	SPOP	0.8911	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	DEG_SPOP_SBC_1	328:332	VISTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons