DegronMD

Uniprot ID: P16112

Source protein: Aggrecan core protein

Source gene: ACAN

Class: DEG_SPOP_SBC_1

Location: 2212:2216

E3 ligase: SPOP

DEGRON score: 0.6313

ASA_SCORE: 72.56

COIL: 0.6202

CONS_SCORE: 0.6205

DSS_SCORE: 0.5166

HELIX: 0.0198

FCONS_SCORE: 1.0975

RIG_SCORE: 0.7412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2224K	TCGA-77-A5G3	LUSC	TCGA	VISTS	DEG_SPOP_SBC_1	0.1111
p.Q2224K	DO45456	LUSC	ICGC	VISTS	DEG_SPOP_SBC_1	0.1111
p.T2226A	TCGA-AP-A0LM	UCEC	TCGA	VISTS	DEG_SPOP_SBC_1	0.0556
p.T2226A	DO43306	UCEC	ICGC	VISTS	DEG_SPOP_SBC_1	0.0556
p.E2219K	TCGA-DK-A1AC	BLCA	TCGA	VISTS	DEG_SPOP_SBC_1	0.25
p.E2219K	DO514	BLCA	ICGC	VISTS	DEG_SPOP_SBC_1	0.25
p.S2203P	TCGA-DM-A28G	COAD	TCGA	VISTS	DEG_SPOP_SBC_1	0.0833
p.S2203P	DO10750	COAD	ICGC	VISTS	DEG_SPOP_SBC_1	0.0833
p.Q2224H	TCGA-DU-6392	LGG	TCGA	VISTS	DEG_SPOP_SBC_1	0.1111
p.Q2224H	DO22237	LGG	ICGC	VISTS	DEG_SPOP_SBC_1	0.1111
p.P2218Q	TCGA-EB-A1NK	SKCM	TCGA	VISTS	DEG_SPOP_SBC_1	0.2778
p.P2218Q	DO37695	SKCM	ICGC	VISTS	DEG_SPOP_SBC_1	0.2778
p.S2207L	TCGA-FW-A3R5	SKCM	TCGA	VISTS	DEG_SPOP_SBC_1	0.1944
p.S2207L	DO222617	BTCA	ICGC	VISTS	DEG_SPOP_SBC_1	0.1944
p.S2207L	DO37406	SKCM	ICGC	VISTS	DEG_SPOP_SBC_1	0.1944
p.V2211I	TCGA-G3-A7M5	LIHC	TCGA	VISTS	DEG_SPOP_SBC_1	0.3056
p.V2211I	DO52290	LIHC	ICGC	VISTS	DEG_SPOP_SBC_1	0.3056
p.S2203C	TCGA-IR-A3LK	CESC	TCGA	VISTS	DEG_SPOP_SBC_1	0.0833
p.S2203C	DO44299	CESC	ICGC	VISTS	DEG_SPOP_SBC_1	0.0833
p.I2213T	DO233267	GACA	ICGC	VISTS	DEG_SPOP_SBC_1	0.5966
p.E2216V	NB13	autonomic_ganglia	COSMIC	VISTS	DEG_SPOP_SBC_1	0.7693
p.H2214Y	Ca-Ski	cervix	COSMIC	VISTS	DEG_SPOP_SBC_1	0.7229
p.G2226E	SW684	soft_tissue	COSMIC	VISTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2212:2216	VISTS	SPOP	0.6313	More...
P18583	Protein SON	DEG_SPOP_SBC_1	1642:1646	VISTS	SPOP	0.996	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	1680:1684	VISTS	SPOP	0.8674	More...
Q9UPS8	Ankyrin repeat domain-containing protein 26	DEG_SPOP_SBC_1	1632:1636	VISTS	SPOP	0.8911	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	DEG_SPOP_SBC_1	328:332	VISTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons