DegronMD

Uniprot ID: Q9UPS8

Source protein: Ankyrin repeat domain-containing protein 26

Source gene: ANKRD26

Class: DEG_SPOP_SBC_1

Location: 1632:1636

E3 ligase: SPOP

DEGRON score: 0.8911

ASA_SCORE: 70.22

COIL: 0.6554

CONS_SCORE: 0.3211

DSS_SCORE: 0.4976

HELIX: 0.0254

FCONS_SCORE: 0.9849

RIG_SCORE: 0.7257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1644I	TCGA-17-Z031	LUAD	TCGA	VISTS	DEG_SPOP_SBC_1	0.1111
p.I1626V	TCGA-AO-A128	BRCA	TCGA	VISTS	DEG_SPOP_SBC_1	0.1667
p.I1626V	DO5326	BRCA	ICGC	VISTS	DEG_SPOP_SBC_1	0.1667
p.L1625F	TCGA-AP-A0LM	UCEC	TCGA	VISTS	DEG_SPOP_SBC_1	0.1389
p.L1625F	DO43306	UCEC	ICGC	VISTS	DEG_SPOP_SBC_1	0.1389
p.M1645I	TCGA-BR-4184	STAD	TCGA	VISTS	DEG_SPOP_SBC_1	0.0833
p.M1645I	DO38328	STAD	ICGC	VISTS	DEG_SPOP_SBC_1	0.0833
p.E1646D	TCGA-EI-6917	READ	TCGA	VISTS	DEG_SPOP_SBC_1	0.0556
p.E1646D	TCGA-EY-A1G8	UCEC	TCGA	VISTS	DEG_SPOP_SBC_1	0.0556
p.E1646D	DO36881	READ	ICGC	VISTS	DEG_SPOP_SBC_1	0.0556
p.E1646D	DO43578	UCEC	ICGC	VISTS	DEG_SPOP_SBC_1	0.0556
p.T1635I	TCGA-ER-A42L	SKCM	TCGA	VISTS	DEG_SPOP_SBC_1	0.7078
p.T1635I	DO223910	SKCM	ICGC	VISTS	DEG_SPOP_SBC_1	0.7078
p.S1634Y	DO222884	COCA	ICGC	VISTS	DEG_SPOP_SBC_1	0.712
p.S1644R	DO229022	LICA	ICGC	VISTS	DEG_SPOP_SBC_1	0.1111
p.N1642D	SIDM00621	Ewing's Sarcoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.1667
p.N1642D	SIDM00118	Colorectal Carcinoma	GDSC	VISTS	DEG_SPOP_SBC_1	0.1667
p.N1642D	HCC2998	large_intestine	COSMIC	VISTS	DEG_SPOP_SBC_1	0.1667
p.N1642D	EW-13	bone	COSMIC	VISTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2212:2216	VISTS	SPOP	0.6313	More...
P18583	Protein SON	DEG_SPOP_SBC_1	1642:1646	VISTS	SPOP	0.996	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	1680:1684	VISTS	SPOP	0.8674	More...
Q9UPS8	Ankyrin repeat domain-containing protein 26	DEG_SPOP_SBC_1	1632:1636	VISTS	SPOP	0.8911	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	DEG_SPOP_SBC_1	328:332	VISTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons