DegronMD - P16112(ACAN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1793H	TCGA-05-4405	LUAD	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7694
p.P1793H	DO24656	LUAD	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7694
p.V1816D	TCGA-17-Z031	LUAD	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.3056
p.T2011N	TCGA-22-4594	LUSC	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1667
p.T2011N	DO27476	LUSC	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1667
p.T2103K	TCGA-43-2581	LUSC	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.2778
p.T2103K	DO26602	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.2778
p.N2013Y	TCGA-44-7669	LUAD	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1111
p.N2013Y	DO25262	LUAD	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1111
p.G1996E	TCGA-56-A4BW	LUSC	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2778
p.G1996E	DO45441	LUSC	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2778
p.E770K	TCGA-60-2722	LUSC	TCGA	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.3056
p.E770K	TCGA-GF-A6C8	SKCM	TCGA	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.3056
p.E770K	DO26798	LUSC	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.3056
p.E770K	DO48765	SKCM	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.3056
p.Q2224K	TCGA-77-A5G3	LUSC	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.1111
p.Q2224K	DO45456	LUSC	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.1111
p.G1990W	TCGA-86-7701	LUAD	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1111
p.G1990W	DO24441	LUAD	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1111
p.Q1798R	TCGA-86-7955	LUAD	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.Q1798R	TCGA-86-7955	LUAD	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.1111
p.Q1798R	DO23612	LUAD	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.Q1798R	DO23612	LUAD	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.1111
p.S1790F	TCGA-A5-A0G2	UCEC	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6871
p.S1790F	DO41235	UCEC	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6871
p.Q1798K	TCGA-A8-A09R	BRCA	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.Q1798K	TCGA-A8-A09R	BRCA	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.1111
p.Q1798K	DO3542	BRCA	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.Q1798K	DO3542	BRCA	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.1111
p.D1784N	TCGA-AG-3906	READ	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.2778
p.D1784N	DO36491	READ	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.2778
p.G1797E	TCGA-AJ-A3NG	UCEC	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.2778
p.G1797E	TCGA-AJ-A3NG	UCEC	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.0833
p.G1797E	DO41163	UCEC	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.2778
p.G1797E	DO41163	UCEC	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.0833
p.S1790Y	TCGA-AP-A0LM	UCEC	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6009
p.S1790Y	DO43306	UCEC	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6009
p.T2226A	TCGA-AP-A0LM	UCEC	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.0556
p.T2226A	DO43306	UCEC	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.0556
p.T2012I	TCGA-AX-A06F	UCEC	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1389
p.T2012I	DO41752	UCEC	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1389
p.T760I	TCGA-AX-A2HD	UCEC	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.0833
p.T760I	DO42608	UCEC	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.0833
p.G2090E	TCGA-BF-A5ES	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.1389
p.G2090E	DO222562	MELA	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.1389
p.G2090E	DO219456	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.1389
p.T2103A	TCGA-BS-A0TC	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.2778
p.T2103A	DO42400	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.2778
p.A767T	TCGA-BT-A0YX	BLCA	TCGA	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2222
p.A767T	DO516	BLCA	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2222
p.S1786R	TCGA-CG-4466	STAD	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7427
p.S1786R	DO38695	STAD	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7427
p.P2097Q	TCGA-D3-A2JD	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation altering degron motif	0.7035
p.P2097Q	DO37543	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation altering degron motif	0.7035
p.G1824C	TCGA-D3-A3C7	SKCM	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.0833
p.G1824C	DO47569	SKCM	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.0833
p.E2092K	TCGA-D3-A8GI	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.1944
p.E2092K	DO50284	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.1944
p.D2007N	TCGA-D3-A8GM	SKCM	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2778
p.D2007N	DO50288	SKCM	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2778
p.G1811R	TCGA-D6-A6ES	HNSC	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6457
p.G1811R	DO52086	HNSC	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6457
p.G1811R	SIDM00585	Hepatocellular Carcinoma	GDSC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6457
p.G1811R	ACH-000480	Liver Cancer	CCLE	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6457
p.G1811R	HuH-7	liver	COSMIC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6457
p.T747A	TCGA-DI-A1BU	UCEC	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.7139
p.T747A	DO42023	UCEC	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.7139
p.E2219K	TCGA-DK-A1AC	BLCA	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.25
p.E2219K	DO514	BLCA	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.25
p.S2203P	TCGA-DM-A28G	COAD	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.0833
p.S2203P	DO10750	COAD	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.0833
p.Q2224H	TCGA-DU-6392	LGG	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.1111
p.Q2224H	DO22237	LGG	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.1111
p.P2218Q	TCGA-EB-A1NK	SKCM	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.2778
p.P2218Q	DO37695	SKCM	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.2778
p.G1824D	TCGA-ER-A19F	SKCM	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.0833
p.G1824D	DO37679	SKCM	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.0833
p.V1816I	TCGA-FW-A3R5	SKCM	TCGA	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.3056
p.V1816I	DO37406	SKCM	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.3056
p.S2207L	TCGA-FW-A3R5	SKCM	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.1944
p.S2207L	DO222617	BTCA	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.1944
p.S2207L	DO37406	SKCM	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.1944
p.V2211I	TCGA-G3-A7M5	LIHC	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.3056
p.V2211I	DO52290	LIHC	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.3056
p.P2189L	TCGA-GV-A6ZA	BLCA	TCGA	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation altering degron motif	0.7582
p.P2189L	DO49776	BLCA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation altering degron motif	0.7582
p.S2203C	TCGA-IR-A3LK	CESC	TCGA	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.0833
p.S2203C	DO44299	CESC	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.0833
p.F2004I	TCGA-L5-A8NE	ESCA	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.6304
p.N738D	TCGA-L5-A8NR	ESCA	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.1667
p.V749L	TCGA-NC-A5HN	LUSC	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.5654
p.V749L	DO52025	LUSC	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.5654
p.P2087A	TCGA-NC-A5HP	LUSC	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.0556
p.P2087A	DO219199	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.0556
p.E2102K	TCGA-QB-A6FS	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.3056
p.E2102K	DO48654	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.3056
p.E1788K	TCGA-RP-A693	SKCM	TCGA	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.591
p.E1788K	DO51268	SKCM	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.591
p.P1999S	TCGA-RP-A693	SKCM	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5641
p.P1999S	DO51268	SKCM	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5641
p.E2098K	TCGA-VS-A9V1	CESC	TCGA	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation altering degron motif	0.591
p.E2098K	DO51648	CESC	ICGC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation altering degron motif	0.591
p.S788F	TCGA-YD-A89C	SKCM	TCGA	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.1944
p.S788F	DO219501	SKCM	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.1944
p.E2197K	TCGA-YD-A9TA	SKCM	TCGA	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation rewiring degron network	0.1944
p.E2197K	DO222662	MELA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation rewiring degron network	0.1944
p.E2197K	DO222837	MELA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation rewiring degron network	0.1944
p.E2197K	DO219503	SKCM	ICGC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation rewiring degron network	0.1944
p.E769D	TCGA-ZS-A9CD	LIHC	TCGA	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2778
p.E769D	DO52334	LIHC	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2778
p.E769D	SIDM00251	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2778
p.E769D	ACH-000949	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2778
p.E769D	TGBC11TKB	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2778
p.P793S	DO222737	COCA	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.0556
p.P793S	DO38376	STAD	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.0556
p.S776C	DO223014	ESCA	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.7541
p.I2213T	DO233267	GACA	ICGC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation altering degron motif	0.5966
p.S1989Y	DO233823	GACA	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0833
p.S771R	DO228357	LICA	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.7427
p.Q1798H	DO228976	LICA	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.Q1798H	DO228976	LICA	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.1111
p.G1818C	DO229018	LICA	ICGC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation rewiring degron network	0.25
p.E2180D	DO229019	LICA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation rewiring degron network	0.1944
p.S1786I	DO229025	LICA	ICGC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7341
p.G2000V	DO229041	LICA	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.6421
p.G750S	DO50970	LICA	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.5882
p.G750S	SIDM00002	Neuroblastoma	GDSC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.5882
p.G750S	ACH-002340	Neuroblastoma	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.5882
p.G750S	NBsusSR	autonomic ganglia	COSMIC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation altering degron motif	0.5882
p.P775H	DO44828	LICA	ICGC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.6583
p.I757T	DO50827	LIRI	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.1667
p.A2009S	DO50729	ORCA	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2222
p.G2200R	DO33808	PACA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation rewiring degron network	0.1111
p.S1790T	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM01096	Colorectal Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM01638	Non-Cancerous	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM00136	Colorectal Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM00172	Head and Neck Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM00310	Mesothelioma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM01765	Osteosarcoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.S1790T	SIDM01546	Kidney Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6005
p.P1779R	SIDM00353	Other Sarcomas	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.1389
p.P1779R	ACH-000505	Sarcoma	CCLE	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.1389
p.P1779R	RKN	ovary	COSMIC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.1389
p.A1808T	SIDM00973	Melanoma	GDSC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6028
p.A1808T	ACH-000827	Skin Cancer	CCLE	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6028
p.A1808T	WM793B	skin	COSMIC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6028
p.G2000S	SIDM01265	Plasma Cell Myeloma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00773	Non-Cancerous	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00967	Ovarian Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00654	Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00878	Breast Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00930	Osteosarcoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00774	Breast Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00257	Neuroblastoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM00785	Acute Myeloid Leukemia	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM01409	Bladder Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.5882
p.G2000R	SIDM00615	Hepatocellular Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.6457
p.G2000R	JHH-6	liver	COSMIC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.6457
p.P759A	SIDM01174	Cervical Carcinoma	GDSC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.1111
p.P759A	ACH-001402	Cervical Cancer	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.1111
p.P759A	SW756	cervix	COSMIC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.1111
p.T778N	SIDM00602	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.5944
p.T778N	ACH-000919	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.5944
p.T778N	IM-95	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.5944
p.T1809A	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.7139
p.T1809A	ACH-002313	Lymphoma	CCLE	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.7139
p.T1809A	TK	haematopoietic and lymphoid tissue	COSMIC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.7139
p.S2192Y	SIDM00193	Colorectal Carcinoma	GDSC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation altering degron motif	0.712
p.S2192Y	ACH-000991	Colon/Colorectal Cancer	CCLE	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation altering degron motif	0.712
p.S2192Y	SNU-81	large intestine	COSMIC	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation altering degron motif	0.712
p.E786K	SIDM00190	Melanoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.25
p.E786K	ACH-002097	Skin Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.25
p.E786K	CP66-MEL	skin	COSMIC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.25
p.A766T	SIDM00294	Small Cell Lung Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.1944
p.S771G	SIDM01146	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.6993
p.S771G	ACH-000932	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.6993
p.S771G	NCI-SNU-1	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.6993
p.S782Y	SIDM01146	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.712
p.S782Y	ACH-000932	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.712
p.S782Y	NCI-SNU-1	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation altering degron motif	0.712
p.T1776S	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.0556
p.T1776S	ACH-000744	Lung Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.0556
p.T1776S	NCI-H1623	lung	COSMIC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.0556
p.S2099C	SIDM00357	Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation altering degron motif	0.7541
p.S2099C	ACH-002193	Lung Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation altering degron motif	0.7541
p.S2099C	RERF-LC-FM	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation altering degron motif	0.7541
p.V2014L	SIDM00006	Other Solid Cancers	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0833
p.V2014L	ACH-001552	Skin Cancer	CCLE	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0833
p.V2014L	MCC26	skin	COSMIC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0833
p.T1783A	SIDM00999	Bladder Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.T1783A	ACH-000973	Bladder Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.T1783A	639-V	urinary tract	COSMIC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.25
p.T2103M	SIDM00850	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.2778
p.T2103M	AGS	stomach	COSMIC	PESSS	DEG_SPOP_SBC_1	2097:2101	Mutation rewiring degron network	0.2778
p.A2009V	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2222
p.A2009V	ACH-000390	Lung Cancer	CCLE	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2222
p.E743G	SIDM01611	Endometrial Carcinoma	GDSC	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.3056
p.E743G	ACH-000996	Endometrial/Uterine Cancer	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.3056
p.D1784E	SIDM00173	Head and Neck Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.2778
p.D1784E	ACH-000618	Head and Neck Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation rewiring degron network	0.2778
p.P2182T	ACH-001510	Head and Neck Cancer	CCLE	PSATPTAS	DEG_SCF_FBW7_1	2185:2192	Mutation rewiring degron network	0.25
p.E737K	ACH-001567	Skin Cancer	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	744:751	Mutation rewiring degron network	0.1389
p.V1792A	ACH-001701	Head and Neck Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.6936
p.E785Q	ACH-001850	Gallbladder Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	771:783	Mutation rewiring degron network	0.2778
p.Q1988K	ACH-001853	Bile Duct Cancer	CCLE	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0556
p.A2002V	SNU-1040	large intestine	COSMIC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.6936
p.E2216V	NB13	autonomic ganglia	COSMIC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation altering degron motif	0.7693
p.H2214Y	Ca-Ski	cervix	COSMIC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation altering degron motif	0.7229
p.G1792R	HuH-7	liver	COSMIC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7568
p.A1789T	WM793B	skin	COSMIC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7139
p.V1995L	MCC26	skin	COSMIC	PPGTPYFS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.25
p.G2226E	SW684	soft tissue	COSMIC	VISTS	DEG_SPOP_SBC_1	2212:2216	Mutation rewiring degron network	0.0556
p.T1790A	TK	haematopoietic and lymphoid tissue	COSMIC	SGETSGVPDL	DEG_COP1_1	1786:1795	Mutation altering degron motif	0.7139
p.V1813L	SW1088	central nervous system	COSMIC	SGATSGVPDL	DEG_COP1_1	1806:1815	Mutation altering degron motif	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACAN

UniProt ID: P16112

Entrez ID: 176

Protein name: Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACAN in