DegronMD

Uniprot ID: P16112

Source protein: Aggrecan core protein

Source gene: ACAN

Class: DEG_COP1_1

Location: 1786:1795

E3 ligase: COP1

DEGRON score: 0.9985

ASA_SCORE: 73.71

COIL: 0.8481

CONS_SCORE: 0.5309

DSS_SCORE: 0.6293

HELIX: 0.0254

FCONS_SCORE: 1.1046

RIG_SCORE: 0.6767

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1793H	TCGA-05-4405	LUAD	TCGA	SGETSGVPDL	DEG_COP1_1	0.7694
p.P1793H	DO24656	LUAD	ICGC	SGETSGVPDL	DEG_COP1_1	0.7694
p.Q1798R	TCGA-86-7955	LUAD	TCGA	SGETSGVPDL	DEG_COP1_1	0.25
p.Q1798R	DO23612	LUAD	ICGC	SGETSGVPDL	DEG_COP1_1	0.25
p.S1790F	TCGA-A5-A0G2	UCEC	TCGA	SGETSGVPDL	DEG_COP1_1	0.6871
p.S1790F	DO41235	UCEC	ICGC	SGETSGVPDL	DEG_COP1_1	0.6871
p.Q1798K	TCGA-A8-A09R	BRCA	TCGA	SGETSGVPDL	DEG_COP1_1	0.25
p.Q1798K	DO3542	BRCA	ICGC	SGETSGVPDL	DEG_COP1_1	0.25
p.D1784N	TCGA-AG-3906	READ	TCGA	SGETSGVPDL	DEG_COP1_1	0.2778
p.D1784N	DO36491	READ	ICGC	SGETSGVPDL	DEG_COP1_1	0.2778
p.G1797E	TCGA-AJ-A3NG	UCEC	TCGA	SGETSGVPDL	DEG_COP1_1	0.2778
p.G1797E	DO41163	UCEC	ICGC	SGETSGVPDL	DEG_COP1_1	0.2778
p.S1790Y	TCGA-AP-A0LM	UCEC	TCGA	SGETSGVPDL	DEG_COP1_1	0.6009
p.S1790Y	DO43306	UCEC	ICGC	SGETSGVPDL	DEG_COP1_1	0.6009
p.S1786R	TCGA-CG-4466	STAD	TCGA	SGETSGVPDL	DEG_COP1_1	0.7427
p.S1786R	DO38695	STAD	ICGC	SGETSGVPDL	DEG_COP1_1	0.7427
p.E1788K	TCGA-RP-A693	SKCM	TCGA	SGETSGVPDL	DEG_COP1_1	0.591
p.E1788K	DO51268	SKCM	ICGC	SGETSGVPDL	DEG_COP1_1	0.591
p.Q1798H	DO228976	LICA	ICGC	SGETSGVPDL	DEG_COP1_1	0.25
p.S1786I	DO229025	LICA	ICGC	SGETSGVPDL	DEG_COP1_1	0.7341
p.S1790T	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM01096	Colorectal Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM01638	Non-Cancerous	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM00136	Colorectal Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM00172	Head and Neck Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM00310	Mesothelioma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM01765	Osteosarcoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.S1790T	SIDM01546	Kidney Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.6005
p.P1779R	SIDM00353	Other Sarcomas	GDSC	SGETSGVPDL	DEG_COP1_1	0.1389
p.P1779R	ACH-000505	Sarcoma	CCLE	SGETSGVPDL	DEG_COP1_1	0.1389
p.P1779R	RKN	ovary	COSMIC	SGETSGVPDL	DEG_COP1_1	0.1389
p.T1776S	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.0556
p.T1776S	ACH-000744	Lung Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	0.0556
p.T1776S	NCI-H1623	lung	COSMIC	SGETSGVPDL	DEG_COP1_1	0.0556
p.T1783A	SIDM00999	Bladder Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.25
p.T1783A	ACH-000973	Bladder Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	0.25
p.T1783A	639-V	urinary_tract	COSMIC	SGETSGVPDL	DEG_COP1_1	0.25
p.D1784E	SIDM00173	Head and Neck Carcinoma	GDSC	SGETSGVPDL	DEG_COP1_1	0.2778
p.D1784E	ACH-000618	Head and Neck Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	0.2778
p.V1792A	ACH-001701	Head and Neck Cancer	CCLE	SGETSGVPDL	DEG_COP1_1	0.6936
p.G1792R	HuH-7	liver	COSMIC	SGETSGVPDL	DEG_COP1_1	0.7568
p.A1789T	WM793B	skin	COSMIC	SGETSGVPDL	DEG_COP1_1	0.7139
p.T1790A	TK	haematopoietic_and_lymphoid_tissue	COSMIC	SGETSGVPDL	DEG_COP1_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGETSGVPDL

Degron related mutations and impact score

Drug responses associated with ACAN mutations

All proteins holding degron of SGETSGVPDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_COP1_1	1786:1795	SGETSGVPDL	COP1	0.9985	More...