DegronMD

Uniprot ID: P16112

Source protein: Aggrecan core protein

Source gene: ACAN

Class: DEG_COP1_1

Location: 771:783

E3 ligase: COP1

DEGRON score: 0.992

ASA_SCORE: 76.1

COIL: 0.8628

CONS_SCORE: 0.4135

DSS_SCORE: 0.8454

HELIX: 0.0434

FCONS_SCORE: 1.3294

RIG_SCORE: 0.5662

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E770K	TCGA-60-2722	LUSC	TCGA	STEGPSATEVPSA	DEG_COP1_1	0.3056
p.E770K	TCGA-GF-A6C8	SKCM	TCGA	STEGPSATEVPSA	DEG_COP1_1	0.3056
p.E770K	DO26798	LUSC	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.3056
p.E770K	DO48765	SKCM	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.3056
p.A767T	TCGA-BT-A0YX	BLCA	TCGA	STEGPSATEVPSA	DEG_COP1_1	0.2222
p.A767T	DO516	BLCA	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.2222
p.S788F	TCGA-YD-A89C	SKCM	TCGA	STEGPSATEVPSA	DEG_COP1_1	0.1944
p.S788F	DO219501	SKCM	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.1944
p.E769D	TCGA-ZS-A9CD	LIHC	TCGA	STEGPSATEVPSA	DEG_COP1_1	0.2778
p.E769D	DO52334	LIHC	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.2778
p.E769D	SIDM00251	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	0.2778
p.E769D	ACH-000949	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	0.2778
p.E769D	TGBC11TKB	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	0.2778
p.P793S	DO222737	COCA	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.0556
p.P793S	DO38376	STAD	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.0556
p.S776C	DO223014	ESCA	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.7541
p.S771R	DO228357	LICA	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.7427
p.P775H	DO44828	LICA	ICGC	STEGPSATEVPSA	DEG_COP1_1	0.6583
p.T778N	SIDM00602	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	0.5944
p.T778N	ACH-000919	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	0.5944
p.T778N	IM-95	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	0.5944
p.E786K	SIDM00190	Melanoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	0.25
p.E786K	ACH-002097	Skin Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	0.25
p.E786K	CP66-MEL	skin	COSMIC	STEGPSATEVPSA	DEG_COP1_1	0.25
p.A766T	SIDM00294	Small Cell Lung Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	0.1944
p.S771G	SIDM01146	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	0.6993
p.S771G	ACH-000932	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	0.6993
p.S771G	NCI-SNU-1	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	0.6993
p.S782Y	SIDM01146	Gastric Carcinoma	GDSC	STEGPSATEVPSA	DEG_COP1_1	0.712
p.S782Y	ACH-000932	Gastric Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	0.712
p.S782Y	NCI-SNU-1	stomach	COSMIC	STEGPSATEVPSA	DEG_COP1_1	0.712
p.E785Q	ACH-001850	Gallbladder Cancer	CCLE	STEGPSATEVPSA	DEG_COP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: STEGPSATEVPSA

Degron related mutations and impact score

Drug responses associated with ACAN mutations

All proteins holding degron of STEGPSATEVPSA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_COP1_1	771:783	STEGPSATEVPSA	COP1	0.992	More...