DegronMD

Uniprot ID: P16112

Source protein: Aggrecan core protein

Source gene: ACAN

Class: DEG_COP1_1

Location: 1806:1815

E3 ligase: COP1

DEGRON score: 0.9458

ASA_SCORE: 73.2

COIL: 0.8591

CONS_SCORE: 0.4422

DSS_SCORE: 0.5485

HELIX: 0.0215

FCONS_SCORE: 0.8688

RIG_SCORE: 0.6615

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1816D	TCGA-17-Z031	LUAD	TCGA	SGATSGVPDL	DEG_COP1_1	0.3056
p.Q1798R	TCGA-86-7955	LUAD	TCGA	SGATSGVPDL	DEG_COP1_1	0.1111
p.Q1798R	DO23612	LUAD	ICGC	SGATSGVPDL	DEG_COP1_1	0.1111
p.Q1798K	TCGA-A8-A09R	BRCA	TCGA	SGATSGVPDL	DEG_COP1_1	0.1111
p.Q1798K	DO3542	BRCA	ICGC	SGATSGVPDL	DEG_COP1_1	0.1111
p.G1797E	TCGA-AJ-A3NG	UCEC	TCGA	SGATSGVPDL	DEG_COP1_1	0.0833
p.G1797E	DO41163	UCEC	ICGC	SGATSGVPDL	DEG_COP1_1	0.0833
p.G1824C	TCGA-D3-A3C7	SKCM	TCGA	SGATSGVPDL	DEG_COP1_1	0.0833
p.G1824C	DO47569	SKCM	ICGC	SGATSGVPDL	DEG_COP1_1	0.0833
p.G1811R	TCGA-D6-A6ES	HNSC	TCGA	SGATSGVPDL	DEG_COP1_1	0.6457
p.G1811R	DO52086	HNSC	ICGC	SGATSGVPDL	DEG_COP1_1	0.6457
p.G1811R	SIDM00585	Hepatocellular Carcinoma	GDSC	SGATSGVPDL	DEG_COP1_1	0.6457
p.G1811R	ACH-000480	Liver Cancer	CCLE	SGATSGVPDL	DEG_COP1_1	0.6457
p.G1811R	HuH-7	liver	COSMIC	SGATSGVPDL	DEG_COP1_1	0.6457
p.G1824D	TCGA-ER-A19F	SKCM	TCGA	SGATSGVPDL	DEG_COP1_1	0.0833
p.G1824D	DO37679	SKCM	ICGC	SGATSGVPDL	DEG_COP1_1	0.0833
p.V1816I	TCGA-FW-A3R5	SKCM	TCGA	SGATSGVPDL	DEG_COP1_1	0.3056
p.V1816I	DO37406	SKCM	ICGC	SGATSGVPDL	DEG_COP1_1	0.3056
p.Q1798H	DO228976	LICA	ICGC	SGATSGVPDL	DEG_COP1_1	0.1111
p.G1818C	DO229018	LICA	ICGC	SGATSGVPDL	DEG_COP1_1	0.25
p.A1808T	SIDM00973	Melanoma	GDSC	SGATSGVPDL	DEG_COP1_1	0.6028
p.A1808T	ACH-000827	Skin Cancer	CCLE	SGATSGVPDL	DEG_COP1_1	0.6028
p.A1808T	WM793B	skin	COSMIC	SGATSGVPDL	DEG_COP1_1	0.6028
p.T1809A	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	SGATSGVPDL	DEG_COP1_1	0.7139
p.T1809A	ACH-002313	Lymphoma	CCLE	SGATSGVPDL	DEG_COP1_1	0.7139
p.T1809A	TK	haematopoietic_and_lymphoid_tissue	COSMIC	SGATSGVPDL	DEG_COP1_1	0.7139
p.V1813L	SW1088	central_nervous_system	COSMIC	SGATSGVPDL	DEG_COP1_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_COP1_1	1806:1815	SGATSGVPDL	COP1	0.9458	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGATSGVPDL

Degron related mutations and impact score

Drug responses associated with ACAN mutations

All proteins holding degron of SGATSGVPDL