DegronMD

Uniprot ID: P16112

Source protein: Aggrecan core protein

Source gene: ACAN

Class: DEG_SCF_FBW7_1

Location: 1998:2005

E3 ligase: FBXW7

DEGRON score: 0.9753

ASA_SCORE: 78.8625

COIL: 0.8626

CONS_SCORE: 0.4333

DSS_SCORE: 0.6292

HELIX: 0.028

FCONS_SCORE: 0.9578

RIG_SCORE: 0.6496

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2002V	SNU-1040	large_intestine	COSMIC	PPGTPYFS	DEG_SCF_FBW7_1	0.6936
p.G2000R	SIDM00615	Hepatocellular Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.6457
p.G2000R	JHH-6	liver	COSMIC	PPGTPYFS	DEG_SCF_FBW7_1	0.6457
p.G2000V	DO229041	LICA	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	0.6421
p.F2004I	TCGA-L5-A8NE	ESCA	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	0.6304
p.G2000S	SIDM01265	Plasma Cell Myeloma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00773	Non-Cancerous	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00967	Ovarian Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00654	Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00878	Breast Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00930	Osteosarcoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00774	Breast Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00257	Neuroblastoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM00785	Acute Myeloid Leukemia	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM01409	Bladder Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.G2000S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PPGTPYFS	DEG_SCF_FBW7_1	0.5882
p.P1999S	TCGA-RP-A693	SKCM	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	0.5641
p.P1999S	DO51268	SKCM	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	0.5641
p.G1996E	TCGA-56-A4BW	LUSC	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	0.2778
p.G1996E	DO45441	LUSC	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	0.2778
p.D2007N	TCGA-D3-A8GM	SKCM	TCGA	PPGTPYFS	DEG_SCF_FBW7_1	0.2778
p.D2007N	DO50288	SKCM	ICGC	PPGTPYFS	DEG_SCF_FBW7_1	0.2778

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Drug responses associated with ACAN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPGTPYFS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SCF_FBW7_1	1998:2005	PPGTPYFS	FBXW7	0.9753	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPGTPYFS

Degron related mutations and impact score

Drug responses associated with ACAN mutations

All proteins holding degron of PPGTPYFS