DegronMD

Uniprot ID: P16112

Source protein: Aggrecan core protein

Source gene: ACAN

Class: DEG_SCF_FBW7_1

Location: 744:751

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 73.8375

COIL: 0.8663

CONS_SCORE: 0.3816

DSS_SCORE: 0.6685

HELIX: 0.0245

FCONS_SCORE: 0.7965

RIG_SCORE: 0.732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T760I	TCGA-AX-A2HD	UCEC	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	0.0833
p.T760I	DO42608	UCEC	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	0.0833
p.T747A	TCGA-DI-A1BU	UCEC	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	0.7139
p.T747A	DO42023	UCEC	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	0.7139
p.N738D	TCGA-L5-A8NR	ESCA	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	0.1667
p.V749L	TCGA-NC-A5HN	LUSC	TCGA	PAYTPVGT	DEG_SCF_FBW7_1	0.5654
p.V749L	DO52025	LUSC	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	0.5654
p.G750S	DO50970	LICA	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	0.5882
p.G750S	SIDM00002	Neuroblastoma	GDSC	PAYTPVGT	DEG_SCF_FBW7_1	0.5882
p.G750S	ACH-002340	Neuroblastoma	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	0.5882
p.G750S	NBsusSR	autonomic_ganglia	COSMIC	PAYTPVGT	DEG_SCF_FBW7_1	0.5882
p.I757T	DO50827	LIRI	ICGC	PAYTPVGT	DEG_SCF_FBW7_1	0.1667
p.P759A	SIDM01174	Cervical Carcinoma	GDSC	PAYTPVGT	DEG_SCF_FBW7_1	0.1111
p.P759A	ACH-001402	Cervical Cancer	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	0.1111
p.P759A	SW756	cervix	COSMIC	PAYTPVGT	DEG_SCF_FBW7_1	0.1111
p.E743G	SIDM01611	Endometrial Carcinoma	GDSC	PAYTPVGT	DEG_SCF_FBW7_1	0.3056
p.E743G	ACH-000996	Endometrial/Uterine Cancer	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	0.3056
p.E737K	ACH-001567	Skin Cancer	CCLE	PAYTPVGT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SCF_FBW7_1	744:751	PAYTPVGT	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons