DegronMD

Uniprot ID: P16112

Source protein: Aggrecan core protein

Source gene: ACAN

Class: DEG_SCF_FBW7_1

Location: 2185:2192

E3 ligase: FBXW7

DEGRON score: 0.9868

ASA_SCORE: 72.6375

COIL: 0.8966

CONS_SCORE: 0.5337

DSS_SCORE: 0.729

HELIX: 0.023

FCONS_SCORE: 1.1452

RIG_SCORE: 0.6354

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2189L	TCGA-GV-A6ZA	BLCA	TCGA	PSATPTAS	DEG_SCF_FBW7_1	0.7582
p.P2189L	DO49776	BLCA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	0.7582
p.E2197K	TCGA-YD-A9TA	SKCM	TCGA	PSATPTAS	DEG_SCF_FBW7_1	0.1944
p.E2197K	DO222662	MELA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	0.1944
p.E2197K	DO222837	MELA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	0.1944
p.E2197K	DO219503	SKCM	ICGC	PSATPTAS	DEG_SCF_FBW7_1	0.1944
p.E2180D	DO229019	LICA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	0.1944
p.G2200R	DO33808	PACA	ICGC	PSATPTAS	DEG_SCF_FBW7_1	0.1111
p.S2192Y	SIDM00193	Colorectal Carcinoma	GDSC	PSATPTAS	DEG_SCF_FBW7_1	0.712
p.S2192Y	ACH-000991	Colon/Colorectal Cancer	CCLE	PSATPTAS	DEG_SCF_FBW7_1	0.712
p.S2192Y	SNU-81	large_intestine	COSMIC	PSATPTAS	DEG_SCF_FBW7_1	0.712
p.P2182T	ACH-001510	Head and Neck Cancer	CCLE	PSATPTAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16112	Aggrecan core protein	DEG_SCF_FBW7_1	2185:2192	PSATPTAS	FBXW7	0.9868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons